Research Article
CACNA1B (Cav2.2) Overexpression and Its Association with Clinicopathologic Characteristics and Unfavorable Prognosis in Non-Small Cell Lung Cancer
Table 1
Correlation of CACNA1B (
2.2) expression in tumor tissues with clinicopathologic characteristics in non-small cell lung cancer (NSCLC) patients.
| | Clinicopathologic characteristics | | CACNA1B (2.2) | | Low or no expression | High expression | Pearson χ2 | |
| | Total | 140 | 58 (41.43) | 82 (58.57) | 29.594 | | | Gender | | | | | | | Male | 69 | 22 (31.88) | 47 (68.12) | 5.108 | 0.018 | | Female | 71 | 36 (50.70) | 35 (49.30) | | | | Age at diagnosis (years) | | | | | | | ≤60 | 66 | 26 (39.39) | 40 (60.61) | 2.063 | 0.103 | | >60 | 74 | 32 (43.24) | 42 (56.76) | | | | Tumor size (cm) | | | | | | | ≤3 | 75 | 40 (53.33) | 35 (46.67) | 9.435 | 0.002 | | >3 | 65 | 18 (27.69) | 47 (72.31) | | | | Histopathology grading | | | | | | | Adenocarcinoma | 92 | 45 (48.91) | 47 (51.09) | 9.222 | 0.010 | | Squamous cell carcinoma | 30 | 11 (36.67) | 19 (63.33) | | | | Others | 18 | 2 (11.11) | 16 (88.89) | | | | Lymph node metastasis | | | | | | | No regional lymph node metastasis | 98 | 49 (50.00) | 49 (50.00) | | | | Metastasis in ipsilateral peribronchial lymph nodes | 22 | 6 (27.27) | 16 (72.73) | 10.541 | 0.005 | | Metastasis in mediastinal lymph nodes | 20 | 3 (15.00) | 17 (85.00) | | | | Smoking | | | | | | | Smoking | 20 | 4 (20.00) | 16 (80.00) | 4.415 | 0.029 | | No smoking | 120 | 54 (45.00) | 66 (55.00) | | | | Stage grouping with TNM | | | | | | | Stage I | 21 | 8 (38.10) | 13 (61.90) | 1.730 | 0.421 | | Stage II | 46 | 16 (34.78) | 30 (65.22) | | | | Stage III | 73 | 34 (46.58) | 39 (53.42) | | |
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; a, others, adenosquamous carcinoma.
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