Differential Expression of Glycolysis-Related Proteins in Follicular Neoplasms versus Hürthle Cell Neoplasms: A Retrospective Analysis

Table 6

Cox-proportional hazard analysis for disease-free survival in follicular carcinomas and Hürthle cell carcinomas.

Parameter	Univariate analysis			Multivariate analysis
	Odd ratio	95% CI	value	Odd ratio	95% CI	value
Age ≥ 45 (years)	3.656	0.789–16.934	0.097
Female sex	0.208	0.063–0.683	0.009	0.201	0.061–0.660	0.008
Tumor size >2.0 (cm)	5.363	0.686–41.910	0.109
Capsular invasion	1.320	0.169–10.316	0.790
Vascular invasion	3.204	0.938–10.946	0.063
Extrathyroidal extension	4.753	1.447–15.612	0.010	4.937	1.503–16.208	0.008
Lymph node metastasis	n/a	n/a	n/a
GLUT-1 positivity	n/a	n/a	n/a
Hexokinase II positivity	0.523	0.113–2.422	0.407
CAIX positivity	n/a	n/a	n/a
MCT4 (T) positivity	0.264	0.033–2.066	0.204
Glycolysis type	n/a	n/a	n/a

n/a: not applicable. Glycolysis type was defined as those positive for two or more of the glycolysis related proteins.