Differential Expression of Glycolysis-Related Proteins in Follicular Neoplasms versus Hürthle Cell Neoplasms: A Retrospective Analysis

Table 7

Cox-proportional hazard analysis for overall survival in follicular carcinomas and Hürthle cell carcinomas.

Parameter	Univariate analysis			Multivariate analysis
	Odd ratio	95% CI	value	Odd ratio	95% CI	value
Age ≥ 45 (years)	0.017	0.001–23.502	0.270
Female sex	0.326	0.053–1.994	0.225
Tumor size >2.0 (cm)	2.151	0.240–19.242	0.493
Capsular invasion	0.546	0.060–4.899	0.589
Vascular invasion	2.530	0.421–15.201	0.310
Extrathyroidal extension	3.903	0.651–23.401	0.136
Lymph node metastasis	15.742	1.723–143.770	0.014	15.742	1.723–143.770	0.014
GLUT-1 positivity	n/a	n/a	n/a
Hexokinase II positivity	n/a	n/a	n/a
CAIX positivity	n/a	n/a	n/a
MCT4 (T) positivity	0.790	0.087–7.225	0.838
Glycolysis type	n/a	n/a	n/a

n/a: not applicable. Glycolysis type was defined as those positive for two or more of the glycolysis related proteins.