Research Article
FOXP3 Allelic Variants and Haplotype Structures Are Associated with Aggressive Breast Cancer Subtypes
Table 2
Allelic, genotypic, and haplotype frequencies of FOXP3 polymorphisms in total BC sample and in aggressive subtypes.
| | Genotype | Controls () | Total BC () | LB () | HER2+ () | TN () |
| | g.10403A>G (rs2232365) | AA | 47 (15.7%) | 26 (22.2%) | 9 (24.3%) | 5 (19.2%) | 12 (22.2%) | | AG | 147 (49.0%) | 54 (46.2%) | 15 (40.6%) | 13 (50.0%) | 26 (48.2%) | | GG | 106 (35.3%) | 37 (31.6%) | 13 (35.1%) | 8 (30.8%) | 16 (29.6%) | | Allele A | 40.2% | 45.3% | 44.6% | 44.2% | 46.3% | | Allele G | 59.8% | 54.7% | 55.4% | 55.8% | 53.7% |
| | g.8048A>C (rs3761548) | AA | 41 (13.7%) | 14 (12%) | 7 (18.9%) | 4 (15.4%) | 3 (5.6%) | | AC | 132 (44.0%) | 48 (41%) | 16 (43.3%) | 10 (38.5%) | 22 (40.7%) | | CC | 127 (42.3%) | 55 (47%) | 14 (37.8%) | 12 (46.1%) | 29 (53.7%) | | Allele A | 35.7% | 32.5% | 40.5% | 34.6% | 25.9% | | Allele C | 64.3% | 67.5% | 59.5% | 65.4% | 74.1% |
| | Haplotypes | AA | 7 (1.2%) | 3 (1.3%) | 2 (2.7%) | 1 (1.9%) | 0 (0%) | | AC | 235 (39.2%) | 104 (44.4%) | 31 (41.9%) | 22 (42.3%) | 51 (47.2%) | | GA | 208 (34.6%) | 73 (31.2%) | 28 (37.8%) | 17 (32.7%) | 28 (25.9%) | | GC | 150 (25%) | 54 (23.1%) | 13 (17.6%) | 12 (23.1%) | 29 (26.9%) |
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LB: Luminal B HER2+; HER2+: HER2-enriched; TN: triple negative.
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