FOXP3 Allelic Variants and Haplotype Structures Are Associated with Aggressive Breast Cancer Subtypes

Table 4

FOXP3 haplotypes correlation analysis in relation to prognostic parameters in total BC sample and aggressive subtypes.

	Clinical outcomes	Haplotypes
		AC	GA	GC
Total BC	TNM staging	0.07 (τ = −0.16)	0.885 (τ = 0.01)	0.06 (τ = 0.18)
	Histological grade	0.415 (τ = 0.07)	0.07 (τ = −0.17)	0.377 (τ = 0.08)
	Tumor size	0.572 (τ = 0.05)	0.157 (τ = −0.12)	0.853 (τ = 0.01)
	Ki-67 index	0.374 (τ = −0.09)	0.517 (τ = 0.06)	0.809 (τ = 0.03)
	LP commitment	0.309 (τ = −0.09)	0.825 (τ = 0.02)	0.443 (τ = 0.07)
LB	TNM staging	0.256 (τ = −0.18)	0.656 (τ = −0.07)	0.330 (τ = 0.17)
	Histological grade	0.771 (τ = −0.05)	0.597 (τ = −0.09)	0.392 (τ = 0.13)
	Tumor size	0.836 (τ = −0.03)	0.491 (τ = −0.10)	0.257 (τ = 0.17)
	Ki-67 index	0.970 (τ = −0.01)	0.118 (τ = 0.25)	0.177 (τ = −0.26)
	LP commitment	0.135 (τ = −0.23)	0.972 (τ = 0.01)	0.295 (τ = 0.17)
HER2+	TNM staging	0.875 (τ = 0.03)	0.186 (τ = −0.24)	0.06 (τ = 0.34)
	Histological grade	0.104 (τ = 0.31)	0.009 (τ = −0.15)	0.968 (τ = 0.01)
	Tumor size	0.491 (τ = −0.13)	0.811 (τ = −0.04)	0.976 (τ = 0.01)
	Ki-67 index	0.005 (τ = −0.54)	0.036 (τ = 0.43)	0.876(τ = −0.04)
	LP commitment	0.756 (τ = −0.06)	0.373 (τ = 0.17)	0.955 (τ = −0.01)
TN	TNM staging	0.027 (τ = −0.29)	0.044 (τ = 0.29)	0.591 (τ = 0.08)
	Histological grade	0.861 (τ = 0.02)	0.705 (τ = −0.06)	0.750 (τ = 0.04)
	Tumor size	0.315 (τ = 0.13)	0.419 (τ = −0.10)	0.502 (τ = −0.09)
	Ki-67 index	0.632 (τ = −0.06)	0.708 (τ = −0.05)	0.533 (τ = 0.09)
	LP commitment	0.883 (τ = −0.02)	0.913 (τ = −0.02)	0.833 (τ = 0.03)

Kendall’s tau test; value of was considered statistically significant. LP: lymph node.