Laboratory and Genetic Biomarkers Associated with Cerebral Blood Flow Velocity in Hemoglobin SC Disease
Table 2
Comparison of laboratory data of children with HbSC with TAMMV velocities defined using a cutoff value of 125.75 cm/s (75th percentile).
Laboratory value
TAMMV < 125.75 cm/s
TAMMV ≥ 125.75 cm/s
value
N
Mean ± SD
N
Mean ± SD
Hemolysis markers
RBC, ×1012/L
46
4.44 ± 0.48
16
4.18 ± 0.49
0.073
Hemoglobin, g/dL
46
11.58 ± 0.81
16
11.04 ± 1.12
0.042
Hematocrit, %
46
33.40 ± 2.45
16
31.68 ± 3.59
0.037
MCV, fL
46
75.63 ± 5.63
16
75.87 ± 3.77
0.877
MCH, ρg
46
26.30 ± 2.53
16
26.48 ± 1.58
0.783
MCHC, g/dL
46
34.90 ± 0.76
16
34.95 ± 0.79
0.532
RDW, %
46
16.00 ± 1.34
16
15.19 ± 0.90
0.010
Reticulocyte count, %
45
4.05 ± 1.94
16
3.74 ± 1.62
0.787†
Total bilirubin, mg/dL
51
1.27 ± 1.15
17
1.08 ± 0.89
0.237†
Direct bilirubin, mg/dL
51
0.30 ± 0.13
17
0.27 ± 0.14
0.288†
Indirect bilirubin, mg/dL
51
0.97 ± 1.08
17
0.80 ± 0.77
0.357†
LDH, U/L
50
584.92 ± 201.47
15
531.67 ± 110.50
0.528†
NOx, μM
50
31.56 ± 6.36
16
27.75 ± 4.20
0.029
Iron metabolism
Serum iron, mcg/dL
49
69.30 ± 22.89
16
77.88 ± 22.91
0.180†
Ferritin, ηg/mL
47
102.82 ± 62.63
17
177.50 ± 202.97
0.029†
RBC: red blood cells; MCV: mean cell volume; MCH: mean cell hemoglobin; MCHC: mean corpuscular hemoglobin concentration; RDW: red cell distribution width; LDH: lactate dehydrogenase; NOx: nitric oxide metabolites; SD: standard deviation; significant values are shown in bold. value using t-test; † value using Mann–Whitney.
