Table of Contents Author Guidelines Submit a Manuscript
Disease Markers
Volume 2017 (2017), Article ID 6807452, 8 pages
https://doi.org/10.1155/2017/6807452
Research Article

Polymorphisms in lncRNA PTENP1 and the Risk of Gastric Cancer in a Chinese Population

1Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
2Suzhou Cancer Center Core Laboratory, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou, Jiangsu, China

Correspondence should be addressed to Li Yang; moc.361@ilgnaykwp and Jundong Zhou; moc.361@033gnodnujuohz

Received 28 April 2017; Revised 3 July 2017; Accepted 2 August 2017; Published 28 August 2017

Academic Editor: Dianjianyi Sun

Copyright © 2017 Yugang Ge et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. A. Torre, F. Bray, R. L. Siegel, J. Ferlay, J. Lortet-Tieulent, and A. Jemal, “Global cancer statistics, 2012,” CA: A Cancer Journal for Clinicians, vol. 65, pp. 87–108, 2015. View at Publisher · View at Google Scholar · View at Scopus
  2. W. Chen, R. Zheng, P. D. Baade et al., “Cancer statistics in China, 2015,” CA: a Cancer Journal for Clinicians, vol. 66, pp. 115–132, 2016. View at Publisher · View at Google Scholar · View at Scopus
  3. H. Berger, M. S. Marques, R. Zietlow, T. F. Meyer, J. C. Machado, and C. Figueiredo, “Gastric cancer pathogenesis,” Helicobacter, vol. 21, Supplement 1, pp. 34–38, 2016. View at Publisher · View at Google Scholar · View at Scopus
  4. Y. Wu, Z. Jia, D. Cao et al., “Predictive value of MiR-219-1, MiR-938, MiR-34b/c, and MiR-218 polymorphisms for gastric cancer susceptibility and prognosis,” Disease Markers, vol. 2017, Article ID 4731891, 9 pages, 2017. View at Publisher · View at Google Scholar
  5. X. Ma, C. Huang, D. Luo et al., “Tag SNPs of long non-coding RNA TINCR affect the genetic susceptibility to gastric cancer in a Chinese population,” Oncotarget, vol. 7, pp. 87114–87123, 2016. View at Publisher · View at Google Scholar
  6. C. Huang, Y. Wang, H. Fan et al., “Association analysis of DACT1 genetic variants and gastric cancer risk in a Chinese Han population: a case-control study,” OncoTargets and Therapy, vol. 9, pp. 5975–5983, 2016. View at Publisher · View at Google Scholar · View at Scopus
  7. D. Luo, Y. Wang, X. Huan et al., “Identification of a synonymous variant in TRIM59 gene for gastric cancer risk in a Chinese population,” Oncotarget, vol. 8, pp. 11507–11516, 2017. View at Publisher · View at Google Scholar
  8. T. Gutschner and S. Diederichs, “The hallmarks of cancer: a long non-coding RNA point of view,” RNA Biology, vol. 9, pp. 703–719, 2012. View at Publisher · View at Google Scholar · View at Scopus
  9. R. Zhang, Y. Guo, Z. Ma et al., “Long non-coding RNA PTENP1 functions as a ceRNA to modulate PTEN level by decoying miR-106b and miR-93 in gastric cancer,” Oncotarget, vol. 8, no. 16, pp. 26079–26089, 2017. View at Publisher · View at Google Scholar
  10. C. L. Chen, Y. W. Tseng, J. C. Wu et al., “Suppression of hepatocellular carcinoma by baculovirus-mediated expression of long non-coding RNA PTENP1 and MicroRNA regulation,” Biomaterials, vol. 44, pp. 71–81, 2015. View at Publisher · View at Google Scholar · View at Scopus
  11. G. Yu, W. Yao, K. Gumireddy et al., “Pseudogene PTENP1 functions as a competing endogenous RNA to suppress clear-cell renal cell carcinoma progression,” Molecular Cancer Therapeutics, vol. 13, pp. 3086–3097, 2014. View at Publisher · View at Google Scholar · View at Scopus
  12. J. Liu, Y. Xing, L. Xu, W. Chen, W. Cao, and C. Zhang, “Decreased expression of pseudogene PTENP1 promotes malignant behaviours and is associated with the poor survival of patients with HNSCC,” Scientific Reports, vol. 7, article 41179, 2017. View at Publisher · View at Google Scholar
  13. L. Poliseno, A. Haimovic, P. J. Christos et al., “Deletion of PTENP1 pseudogene in human melanoma,” The Journal of Investigative Dermatology, vol. 131, pp. 2497–2500, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. Y. J. Ioffe, K. B. Chiappinelli, D. G. Mutch, I. Zighelboim, and P. J. Goodfellow, “Phosphatase and tensin homolog (PTEN) pseudogene expression in endometrial cancer: a conserved regulatory mechanism important in tumorigenesis?” Gynecologic Oncology, vol. 124, pp. 340–346, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. L. Gao, W. Ren, L. Zhang et al., “PTENp1, a natural sponge of miR-21, mediates PTEN expression to inhibit the proliferation of oral squamous cell carcinoma,” Molecular Carcinogenesis, vol. 56, pp. 1322–1334, 2017. View at Publisher · View at Google Scholar · View at Scopus
  16. X. Guo, L. Deng, K. Deng et al., “Pseudogene PTENP1 suppresses gastric cancer progression by modulating PTEN,” Anti-Cancer Agents in Medicinal Chemistry, vol. 16, pp. 456–464, 2016. View at Google Scholar
  17. L. Dong, P. Qi, M. D. Xu et al., “Circulating CUDR, LSINCT-5 and PTENP1 long noncoding RNAs in sera distinguish patients with gastric cancer from healthy controls,” International Journal of Cancer, vol. 137, pp. 1128–1135, 2015. View at Publisher · View at Google Scholar · View at Scopus
  18. J. Liu, L. Sun, Q. Xu et al., “Association of nucleotide excision repair pathway gene polymorphisms with gastric cancer and atrophic gastritis risks,” Oncotarget, vol. 7, pp. 6972–6983, 2016. View at Publisher · View at Google Scholar · View at Scopus
  19. Y. Xue, D. Gu, G. Ma et al., “Genetic variants in lncRNA HOTAIR are associated with risk of colorectal cancer,” Mutagenesis, vol. 30, pp. 303–310, 2015. View at Publisher · View at Google Scholar · View at Scopus
  20. H. Ma, Y. Shu, S. Pan et al., “Polymorphisms of key chemokine genes and survival of non-small cell lung cancer in Chinese,” Lung Cancer, vol. 74, pp. 164–169, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. R. Niu, Y. Wang, M. Zhu et al., “Potentially functional polymorphisms in POU5F1 gene are associated with the risk of lung cancer in Han Chinese,” BioMed Research International, vol. 2015, Article ID 851320, 7 pages, 2015. View at Publisher · View at Google Scholar · View at Scopus
  22. D. Li, X. Liu, J. Zhou et al., “Long noncoding RNA HULC modulates the phosphorylation of YB-1 through serving as a scaffold of extracellular signal-regulated kinase and YB-1 to enhance hepatocarcinogenesis,” Hepatology, vol. 65, pp. 1612–1627, 2017. View at Publisher · View at Google Scholar
  23. J. Su, E. Zhang, L. Han et al., “Long noncoding RNA BLACAT1 indicates a poor prognosis of colorectal cancer and affects cell proliferation by epigenetically silencing of p15,” Cell Death & Disease, vol. 8, article e2665, 2017. View at Publisher · View at Google Scholar
  24. S. Li, Y. Hua, J. Jin et al., “Association of genetic variants in lncRNA H19 with risk of colorectal cancer in a Chinese population,” Oncotarget, vol. 7, pp. 25470–25477, 2016. View at Publisher · View at Google Scholar · View at Scopus
  25. D. M. Parkin, “International variation,” Oncogene, vol. 23, pp. 6329–6340, 2004. View at Publisher · View at Google Scholar · View at Scopus
  26. S. H. Ma, W. Jung, E. Weiderpass et al., “Impact of alcohol drinking on gastric cancer development according to helicobacter pylori infection status,” British Journal of Cancer, vol. 113, pp. 1381–1388, 2015. View at Publisher · View at Google Scholar · View at Scopus
  27. H. Gu, L. Yang, Q. Sun et al., “Gly82Ser polymorphism of the receptor for advanced glycation end products is associated with an increased risk of gastric cancer in a Chinese population,” Clinical Cancer Research, vol. 14, pp. 3627–3632, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. A. R. Gruber, R. Lorenz, S. H. Bernhart, R. Neubock, and I. L. Hofacker, “The Vienna RNA websuite,” Nucleic Acids Research, vol. 36, pp. W70–W74, 2008. View at Publisher · View at Google Scholar · View at Scopus
  29. T. Y. Shi, X. J. Chen, M. L. Zhu et al., “A pri-miR-218 variant and risk of cervical carcinoma in Chinese women,” BMC Cancer, vol. 13, p. 19, 2013. View at Publisher · View at Google Scholar · View at Scopus
  30. G. W. Verhaegh, L. Verkleij, S. H. Vermeulen, M. den Heijer, J. A. Witjes, and L. A. Kiemeney, “Polymorphisms in the H19 gene and the risk of bladder cancer,” European Urology, vol. 54, pp. 1118–1126, 2008. View at Publisher · View at Google Scholar · View at Scopus
  31. X. H. Liu, M. Sun, F. Q. Nie et al., “Lnc RNA HOTAIR functions as a competing endogenous RNA to regulate HER2 expression by sponging miR-331-3p in gastric cancer,” Molecular Cancer, vol. 13, p. 92, 2014. View at Publisher · View at Google Scholar · View at Scopus
  32. J. Lv, H. X. Fan, X. P. Zhao et al., “Long non-coding RNA Unigene56159 promotes epithelial-mesenchymal transition by acting as a ceRNA of miR-140-5p in hepatocellular carcinoma cells,” Cancer Letters, vol. 382, pp. 166–175, 2016. View at Publisher · View at Google Scholar · View at Scopus
  33. H. Y. Huang, C. H. Chien, K. H. Jen, and H. D. Huang, “RegRNA: an integrated web server for identifying regulatory RNA motifs and elements,” Nucleic Acids Research, vol. 34, pp. W429–W434, 2006. View at Google Scholar
  34. T. H. Chang, H. Y. Huang, J. B. Hsu, S. L. Weng, J. T. Horng, and H. D. Huang, “An enhanced computational platform for investigating the roles of regulatory RNA and for identifying functional RNA motifs,” BMC Bioinformatics, vol. 14, Supplement 2, p. S4, 2013. View at Publisher · View at Google Scholar · View at Scopus