Polymorphisms in lncRNA PTENP1 and the Risk of Gastric Cancer in a Chinese Population
Table 2
Association between PTENP1 gene polymorphisms and risk of gastric cancer (rs7853346).
Genotype
Cases N (%)
Controls N (%)
Crude OR (95% CI)
Adjusted OR (95% CI)
c
Overall
768
768
Additive model
0.79 (0.67–0.94)
0.007
0.80 (0.67–0.95)
0.011
0.033
Codominant model
CC
496 (64.6)
447 (58.2)
1
1
CG
241 (31.4)
277 (36.1)
0.78 (0.63–0.97)
0.026
0.79 (0.63–0.98)
0.033
0.099
GG
31 (4.0)
44 (5.7)
0.63 (0.39–1.02)
0.060
0.65 (0.40–1.06)
0.087
0.261
Dominant model
CC
496 (64.6)
447 (58.2)
1
1
CG+GG
272 (35.4)
321 (41.8)
0.76 (0.62–0.94)
0.010
0.77 (0.62–0.95)
0.015
0.045
trend
0.013
0.039
Recessive model
CC+CG
737 (96.0)
724 (94.3)
1
GG
31 (4.0)
44 (5.7)
0.69 (0.43–1.11)
0.124
0.71 (0.44–1.14)
0.153
0.459
Allele
C
1233 (79.8)
1171 (76.2)
1
G
303 (20.2)
365 (23.8)
0.79 (0.66–0.94)
0.007
HWE
0.900
Abbreviations: OR, odds ratio; CI, confidence interval; HWE, Hardy-Weinberg expectations. Adjusted for age, sex, smoking status, drinking status, residence, hypertension, diabetes, and family history of GC in the logistic regression model. c after Bonferroni’s correction. trend for CC, CG, GG, and CG+GG genotypes. The significant results are in bold.
