Polymorphisms in lncRNA PTENP1 and the Risk of Gastric Cancer in a Chinese Population
Table 3
Stratified analyses for PTENP1 genotypes in cases and controls (rs7853346).
Variable
n CG+GG (%)/n CC (%) for rs7853346
Allelic odds ratios and 95% confidence intervals for rs7853346
Cases
Controls
Adjusted OR (95% CI)
value
I2
Heterogeneity
Age (y)
≥60
153 (19.9)/290 (37.8)
165 (21.5)/226 (29.4)
0.72 (0.54–0.96)
0.026
<60
119 (15.5)/206 (26.8)
156 (20.3)/221 (28.8)
0.82 (0.60–1.12)
0.203
0%
0.610
Sex
Females
107 (13.9)/180 (23.4)
143 (18.6)/176 (22.9)
0.72 (0.51–1.00)
0.052
Males
165 (21.5)/316 (41.1)
178 (23.2)/271 (35.3)
0.79 (0.60–1.03)
0.085
0%
0.710
Smoking status
Yes
71 (9.2)/141 (18.4)
57 (7.4)/86 (11.2)
0.76 (0.48–1.22)
0.254
No
201 (26.2)/355 (46.2)
264 (34.4)/361 (47.0)
0.78 (0.61–0.99)
0.037
0%
0.863
Drinking status
Yes
58 (7.6)/117 (15.2)
36 (4.7)/63 (8.2)
0.87 (0.50–1.49)
0.603
No
214 (27.9)/379 (49.3)
285 (37.1)/384 (50.0)
0.75 (0.60–0.95)
0.016
0%
0.718
Residence
Rural
166 (21.6)/274 (35.7)
186 (24.2)/228 (29.7)
0.77 (0.59–1.02)
0.071
Urban
106 (13.8)/222 (28.9)
135 (17.6)/219 (28.5)
0.78 (0.57–1.08)
0.133
0%
0.960
FH
Yes
20 (2.6)/45 (5.9)
20 (2.6)/33 (4.3)
0.69 (0.31–1.55)
0.371
No
252 (32.8)/451 (58.7)
301 (39.2)/414 (53.9)
0.78 (0.62–0.97)
0.023
0%
0.841
OR, odds ratio; CI, confidence interval; FH, family history of GC. Adjusted for age, sex, smoking status, drinking status, residence, hypertension, diabetes, and family history of GC (excluding the stratified factor in each stratum) in the logistic regression model. The significant results are in bold.
