Research Article
Differential Site-Based Expression of Pentose Phosphate Pathway-Related Proteins among Breast Cancer Metastases
Table 3
Expression of pentose phosphate pathway-related proteins according to the metastatic site in breast cancer metastases.
| | Parameter | Total
(%) | Metastatic site | value | Bone
(%) | Brain
(%) | Liver
(%) | Lung
(%) |
| | G6PDH | | | | | | | | Negative | 26 (20.6) | 7 (22.6) | 3 (8.3) | 6 (54.5) | 10 (20.8) | 0.011 | | Positive | 100 (79.4) | 24 (77.4) | 33 (91.7) | 5 (45.5) | 38 (79.2) | | 6PGL | | | | | | | | Negative | 89 (70.6) | 21 (67.7) | 23 (63.9) | 11 (100.0) | 34 (70.8) | 0.139 | | Positive | 37 (29.4) | 10 (32.3) | 13 (36.1) | 0 (0.0) | 14 (29.2) | | 6PGDH | | | | | | | | Negative | 122 (96.8) | 30 (96.8) | 34 (94.4) | 11 (100.0) | 47 (97.9) | 0.750 | | Positive | 4 (3.2) | 1 (3.2) | 2 (5.6) | 0 (0.0) | 1 (2.1) | | NRF2 (cytoplasm) | | | | | | | | Negative | 113 (89.7) | 31 (100.0) | 26 (72.2) | 11 (100.0) | 45 (93.8) | 0.001 | | Positive | 13 (10.3) | 0 (0.0) | 10 (27.8) | 0 (0.0) | 3 (6.3) | | NRF2 (nuclei) | | | | | | | | Negative | 110 (87.3) | 28 (90.3) | 28 (77.8) | 11 (100.0) | 43 (89.6) | 0.170 | | Positive | 16 (12.7) | 3 (9.7) | 8 (22.2) | 0 (0.0) | 5 (10.4) |
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G6PDH, glucose-6-phosphate dehydrogenase; 6PGL, 6-phosphogluconolactonase; 6PGDH, 6-phosphogluconate dehydrogenase; NRF2, nuclear factor erythroid 2- (NF-E2-) related factor 2.
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