Review Article
Association between IL-4 and IL-4R Polymorphisms and Periodontitis: A Meta-Analysis
Table 1
Characteristics of studies included in meta-analysis.
| Study (author, year) | Country | Ethnicity | Disease type | Source | Sample Size case/control | Smoker % | Genotyping method | for HWE | NOS score |
| IL-4 -590C/T | | | | | | | | | | Byung 2003 [7] | Korea | Asian | CP | HB | 32/150 | 37.5 | PCR | 0.28 | 7 | Scarel-Caminaga 2003a [24] | Brazil | Caucasian | CP | HB | 50/37 | 0 | PCR-RFLP | 0.74 | 7 | Scarel-Caminaga 2003b [24] | Brazil | Mixed | CP | HB | 19/7 | 0 | PCR-RFLP | 0.43 | 7 | Gonzales 2004a [15] | Europe | Caucasian | AgP | PB | 30/33 | NA | PCR-RFLP | 0.18 | 7 | Gonzales 2004b [15] | Japan | Asian | AgP | PB | 30/31 | NA | PCR-RFLP | 0.09 | 7 | Gonzales 2007 [6] | Germany | Caucasian | AgP | PB | 58/51 | 12 | PCR-RFLP | 0.83 | 7 | Kara 2007 [20] | Turkey | Caucasian | CP | PB | 75/73 | 0 | PCR-RFLP | 0.48 | 7 | Holla 2008 [17] | Czech | Caucasian | CP | PB | 194/158 | 31.3 | PCR-RFLP | 0.53 | 7 | Hooshmand 2008a [18] | Iran | Asian | CP | PB | 26/56 | 0 | PCR-RFLP | 0.35 | 7 | Hooshmand 2008b [18] | Iran | Asian | AgP | PB | 27/56 | 0 | PCR-RFLP | 0.35 | 7 | Anovazzi 2010 [11] | Brazil | Caucasian | CP | HB | 125/125 | 15.2 | PCR-RFLP | 0.04 | 6 | Atanasovska-Stojanovska 2011 [12] | Macedonia | Caucasian | CP | HB | 92/286 | 0 | PCR-RFLP | <0.05 | 6 | Loo 2012 [22] | China | Asian | CP | PB | 440/850 | NA | PCR | <0.05 | 6 | Chen 2012 [13] | China | Asian | CP | HB | 198/128 | NA | PCR | 0.07 | 7 | Liu 2015 [21] | China | Asian | CP | HB | 104/106 | 27.9 | PCR-RFLP | 0.65 | 7 | IL-4 -33C/T | | | | | | | | | | Gonzales 2007 [6] | Germany | Caucasian | AgP | PB | 58/51 | 12 | PCR-RFLP | 0.67 | 7 | Holla 2008 [17] | Czech | Caucasian | CP | PB | 194/158 | 31.3 | PCR-RFLP | 0.53 | 7 | Anovazzi 2010 [11] | Brazil | Caucasian | CP | HB | 125/125 | 15.2 | PCR-RFLP | <0.05 | 6 | Atanasovska-Stojanovska 2011 [12] | Macedonia | Caucasian | CP | HB | 92/286 | 0 | PCR-RFLP | <0.05 | 6 | Jain 2013a [19] | India | Dravidian | CP | PB | 63/101 | NA | PCR | 0.63 | 7 | Jain 2013b [19] | India | Dravidian | AgP | PB | 61/101 | NA | PCR | 0.63 | 7 | Liu 2015 [21] | China | Asian | CP | HB | 104/106 | 27.9 | PCR-RFLP | 0.65 | 7 | Chen 2016 [14] | China | Asian | CP | HB | 440/324 | 0 | PCR | 1.12 | 7 | IL-4 -1099T/G | | | | | | | | | | Chen 2012 [13] | China | Asian | CP | HB | 278/324 | NA | PCR | <0.05 | 6 | Chen 2016 [14] | China | Asian | CP | HB | 440/324 | 0 | PCR | 0.17 | 7 | IL-4 70 bp repeat | | | | | | | | | | Byung 2003 [7] | Korea | Asian | CP | HB | 32/150 | 37.5 | PCR | 0.27 | 7 | Gonzales 2004a [15] | Europe | Caucasian | AgP | PB | 30/33 | NA | PCR-RFLP | 0.70 | 7 | Gonzales 2004b [15] | Japan | Asian | AgP | PB | 30/31 | NA | PCR-RFLP | 0.16 | 7 | Kara 2007 [20] | Turkey | Caucasian | CP | PB | 75/73 | 0 | PCR-RFLP | 0.36 | 7 | Holla 2008 [17] | Czech | Caucasian | CP | PB | 194/158 | 31.3 | PCR-RFLP | 0.53 | 7 | Anovazzi 2010 [11] | Brazil | Caucasian | CP | HB | 125/125 | 15.2 | PCR | 0.80 | 7 | Grigorovich 2015a [16] | Russian | Caucasian | CP | PB | 150/150 | NA | PCR | 0.80 | 7 | Grigorovich 2015b [16] | Russian | Caucasian | AgP | PB | 150/150 | NA | PCR | 0.80 | 7 | IL-4R Q551R | | | | | | | | | | Donati 2005a [10] | Swedish | Caucasian | CP | PB | 60/39 | 50 | PCR | 0.44 | 7 | Donati 2005b [10] | Swedish | Caucasian | CP | PB | 30/34 | 0 | PCR | 0.32 | 7 | Reichert 2011a [23] | Germany | Caucasian | CP | PB | 68/89 | 25 | PCR-SSP | 0.52 | 7 | Reichert 2011b [23] | Germany | Caucasian | AgP | PB | 86/89 | 35.3 | PCR-SSP | 0.52 | 7 |
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Mixed = Afro-Americans, Mulattos, and Asians. HB = hospital-based. PB = population-based. NA = not available. Smoker % = smoker among patients %.
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