Association between IL-4 and IL-4R Polymorphisms and Periodontitis: A Meta-Analysis

Table 2

Meta-analysis of the association between the IL-4 -590C/T polymorphism and periodontitis.

Genetic model and subgroup	Number of studies	Heterogeneity		Pooled results
			(%)	OR	95% CI	for OR
T versus C
Overall	15	<0.01	90.4%	1.12	(0.75–1.66)	0.59
HWE (Y)	12	0.18	27.1%	1.02	(0.83–1.25)	0.84
Caucasian	9	0.07	45.3%	1.10	(0.86–1.39)	0.48
Non-Caucasian	6	<0.01	94.4%	1.20	(0.54–2.65)	0.66
CP	11	<0.01	92.7%	1.09	(0.68–1.77)	0.72
AgP	4	0.26	25.5%	1.17	(0.77–1.78)	0.45
TT versus CC
Overall	16	<0.01	86.2%	1.44	(0.58–3.57)	0.44
HWE (Y)	12	0.26	19.0%	1.02	(0.62–1.66)	0.94
Caucasian	9	0.63	0.0%	1.54	(0.99–2.41)	0.06
Non-Caucasian	6	<0.01	94.1%	1.67	(0.21–13.57)	0.63
CP	11	<0.01	89.8%	1.41	(0.44–4.53)	0.57
AgP	4	0.42	0.0%	1.72	(0.78–3.80)	0.18
CT versus CC
Overall	15	<0.01	81.0%	1.26	(0.76–2.10)	0.37
HWE (Y)	12	0.24	24.7%	1.00	(0.72–1.38)	0.98
Caucasian	9	<0.01	68.3%	1.02	(0.66–1.58)	0.91
Non-Caucasian	6	<0.01	85.6%	1.93	(0.51–7.27)	0.33
CP	11	<0.01	84.9%	1.90	(0.73–2.58)	0.39
AgP	4	0.16	42.3%	1.90	(0.48–1.89)	0.90
(TT + CT) versus CC
Overall	15	<0.01	85.9%	1.3	(0.74–2.26)	0.36
HWE (Y)	12	0.21	23.7%	1.02	(0.75–1.38)	0.9
Caucasian	9	<0.01	63.9%	1.07	(0.72–1.58)	0.74
Non-Caucasian	6	<0.01	91.4%	1.83	(0.37–8.94)	0.45
CP	11	<0.01	89.3%	1.36	(0.67–2.78)	0.39
AgP	4	0.29	20.5%	1.06	(0.62–1.81)	0.84
TT versus (CC + CT)
Overall	15	<0.01	85.8%	1.20	(0.66–2.19)	0.57
HWE (Y)	12	0.25	19.6%	1.02	(0.73–1.44)	0.90
Caucasian	9	0.46	0.0%	1.35	(0.88–2.06)	0.17
Non-Caucasian	6	<0.01	93.9%	1.11	(0.40–3.04)	0.84
CP	11	<0.01	89.5%	1.11	(0.55–2.27)	0.77
AgP	4	0.35	9.5%	1.83	(0.82–4.12)	0.14

Non-Caucasian = Asian and mixed.