Review Article
Association between IL-4 and IL-4R Polymorphisms and Periodontitis: A Meta-Analysis
Table 3
Meta-analysis of the association between the IL-4 -33C/T polymorphism and periodontitis.
| Genetic model and subgroup | Number of studies | Heterogeneity | Pooled results | | (%) | OR | 95% CI | for OR |
| T versus C | | | | | | | Overall | 8 | <0.0001 | 83.2 | 1.01 | (0.69–1.47) | 0.98 | HWE (yes) | 6 | 0.0848 | 48.3 | 1.02 | (0.78–1.33) | 0.90 | Caucasian | 4 | <0.0001 | 90.7 | 1.15 | (0.57–2.34) | 0.70 | Non-Caucasian | 4 | 0.0491 | 61.8 | 0.90 | (0.61–1.32) | 0.58 | CP | 6 | <0.0001 | 83.2 | 1.07 | (0.68–1.68) | 0.76 | AgP | 2 | 0.0907 | 65.1 | 0.80 | (0.39–1.67) | 0.56 | TT versus CC | | | | | | | Overall | 8 | <0.0001 | 90.7 | 1.15 | (0.57–2.34) | 0.65 | HWE (yes) | 6 | 0.5117 | 0 | 1.32 | (0.82–2.12) | 0.26 | Caucasian | 4 | <0.0001 | 90.3 | 1.57 | (0.39–6.40) | 0.53 | Non-Caucasian | 4 | 0.3466 | 9.3 | 1.06 | (0.51–2.22) | 0.87 | CP | 6 | <0.0001 | 84.7 | 1.28 | (0.45–3.62) | 0.64 | AgP | 2 | 0.1579 | 49.9 | 0.94 | (0.12–7.44) | 0.95 | CT versus CC | | | | | | | Overall | 8 | 0.2100 | 27.4 | 0.83 | (0.61–1.13) | 0.24 | HWE (yes) | 6 | 0.1373 | 40.2 | 0.84 | (0.56–1.25) | 0.39 | Caucasian | 4 | 0.0766 | 56.2 | 0.81 | (0.48–1.36) | 0.42 | Non-Caucasian | 4 | 0.4519 | 0 | 1.81 | (0.54–1.20) | 0.30 | CP | 6 | 0.4406 | 0 | 0.98 | (0.74–1.31) | 0.92 | AgP | 2 | 0.4977 | 0 | 0.50 | (0.28–0.88) | 0.02 | (TT + CT) versus CC | | | | | | | Overall | 8 | 0.0301 | 54.8 | 0.92 | (0.65–1.30) | 0.62 | HWE (yes) | 6 | 0.1742 | 35 | 0.91 | (0.63–1.30) | 0.59 | Caucasian | 4 | 0.0186 | 70 | 1.00 | (0.60–1.64) | 0.98 | Non-Caucasian | 4 | 0.2462 | 27.6 | 0.80 | (0.50–1.28) | 0.35 | CP | 6 | 0.0352 | 58.2 | 1.03 | (0.69–1.54) | 0.88 | AgP | 2 | 0.5803 | 0% | 0.62 | (0.37–1.04) | 0.07 | TT versus (CC + CT) | | | | | | | Overall | 8 | <0.0001 | 90.7 | 1.15 | (0.57–2.34) | 0.65 | HWE (yes) | 6 | 0.5117 | 0 | 1.32 | (0.82–2.12) | 0.26 | Caucasian | 4 | <0.0001 | 90.3 | 1.57 | (0.39–6.40) | 0.53 | Non-Caucasian | 4 | 0.3466 | 9.3 | 1.06 | (0.51–2.22) | 0.40 | CP | 6 | <0.0001 | 84.7 | 1.28 | (0.45–3.62) | 0.64 | AgP | 2 | 0.1579 | 49.9 | 0.94 | (0.12–7.44) | 0.95 |
|
|
Note. Non-Caucasian = Asian, Dravidian.
|