Association between IL-4 and IL-4R Polymorphisms and Periodontitis: A Meta-Analysis

Table 3

Meta-analysis of the association between the IL-4 -33C/T polymorphism and periodontitis.

Genetic model and subgroup	Number of studies	Heterogeneity		Pooled results
			(%)	OR	95% CI	for OR
T versus C
Overall	8	<0.0001	83.2	1.01	(0.69–1.47)	0.98
HWE (yes)	6	0.0848	48.3	1.02	(0.78–1.33)	0.90
Caucasian	4	<0.0001	90.7	1.15	(0.57–2.34)	0.70
Non-Caucasian	4	0.0491	61.8	0.90	(0.61–1.32)	0.58
CP	6	<0.0001	83.2	1.07	(0.68–1.68)	0.76
AgP	2	0.0907	65.1	0.80	(0.39–1.67)	0.56
TT versus CC
Overall	8	<0.0001	90.7	1.15	(0.57–2.34)	0.65
HWE (yes)	6	0.5117	0	1.32	(0.82–2.12)	0.26
Caucasian	4	<0.0001	90.3	1.57	(0.39–6.40)	0.53
Non-Caucasian	4	0.3466	9.3	1.06	(0.51–2.22)	0.87
CP	6	<0.0001	84.7	1.28	(0.45–3.62)	0.64
AgP	2	0.1579	49.9	0.94	(0.12–7.44)	0.95
CT versus CC
Overall	8	0.2100	27.4	0.83	(0.61–1.13)	0.24
HWE (yes)	6	0.1373	40.2	0.84	(0.56–1.25)	0.39
Caucasian	4	0.0766	56.2	0.81	(0.48–1.36)	0.42
Non-Caucasian	4	0.4519	0	1.81	(0.54–1.20)	0.30
CP	6	0.4406	0	0.98	(0.74–1.31)	0.92
AgP	2	0.4977	0	0.50	(0.28–0.88)	0.02
(TT + CT) versus CC
Overall	8	0.0301	54.8	0.92	(0.65–1.30)	0.62
HWE (yes)	6	0.1742	35	0.91	(0.63–1.30)	0.59
Caucasian	4	0.0186	70	1.00	(0.60–1.64)	0.98
Non-Caucasian	4	0.2462	27.6	0.80	(0.50–1.28)	0.35
CP	6	0.0352	58.2	1.03	(0.69–1.54)	0.88
AgP	2	0.5803	0%	0.62	(0.37–1.04)	0.07
TT versus (CC + CT)
Overall	8	<0.0001	90.7	1.15	(0.57–2.34)	0.65
HWE (yes)	6	0.5117	0	1.32	(0.82–2.12)	0.26
Caucasian	4	<0.0001	90.3	1.57	(0.39–6.40)	0.53
Non-Caucasian	4	0.3466	9.3	1.06	(0.51–2.22)	0.40
CP	6	<0.0001	84.7	1.28	(0.45–3.62)	0.64
AgP	2	0.1579	49.9	0.94	(0.12–7.44)	0.95

Note. Non-Caucasian = Asian, Dravidian.