Association between IL-4 and IL-4R Polymorphisms and Periodontitis: A Meta-Analysis

Table 5

Meta-analysis of the association between the IL-4 70 bp VNTR polymorphism and periodontitis.

Genetic model and subgroup	Number of studies	Heterogeneity		Pooled results
			(%)	OR	95% CI	for OR
2 versus 1
Overall	8	<0.01	94.4	1.67	(0.71–3.96)	0.24
Caucasian	6	<0.01	95.8	1.90	(0.64–5.60)	0.25
Asian	2	0.0841	66.5	1.12	(0.46–2.70)	0.81
CP	5	<0.01	96.3	1.76	(0.53–5.85)	0.35
AgP	3	<0.01	88.6	1.54	(0.44–5.34)	0.50
22 versus 11
Overall	8	0.01	61.7	1.39	(0.56–3.42)	0.48
Caucasian	6	0.01	66.9	1.66	(0.56–4.94)	0.36
Asian	2	0.1	56.0	0.79	(0.12–5.13)	0.80
CP	5	0.05	58.7	1.34	(0.53–3.43)	0.54
AgP	3	0.01	76.5	1.63	(0.11–23.69)	0.72
12 versus 11
Overall	8	0.01	76.0	1.00	(0.43–2.31)	1.00
Caucasian	6	<0.01	79.6	0.97	(0.36–2.65)	0.95
Asian	2	0.07	69.2	1.09	(0.15–7.72)	0.94
CP	5	<0.01	82.2	0.82	(0.29–2.26)	0.69
AgP	3	0.16	45.2	1.68	(0.37–7.90)	0.51
(22 + 12) versus 11
Overall	8	<0.01	78.1	1.09	(0.48–2.50)	0.84
Caucasian	6	<0.01	81.7	1.12	(0.41–3.06)	0.83
Asian	2	0.05	72.9	0.99	(0.13–7.29)	0.99
CP	5	<0.01	82.5	0.90	(0.34–2.38)	0.83
AgP	3	0.05	66.8	1.75	(0.24–12.67)	0.58
22 versus (11 + 12)
Overall	8	0.0003	74.1	1.61	(0.89–2.93)	0.12
Caucasian	6	0.0313	59.2	1.65	(0.96–2.85)	0.07
Asian	2	0.55	0.0	0.86	(0.43–1.74)	0.68
CP	5	0.02	67.3	1.66	(0.89–3.08)	0.10
AgP	3	0.0008	86.0	1.37	(0.26–7.22)	0.72

1 for 184 bp, 2 for 254 bp.