Association between IL-4 and IL-4R Polymorphisms and Periodontitis: A Meta-Analysis

Table 6

Meta-analysis of the association between the IL-4 Q551R polymorphism and periodontitis.

Genetic model and subgroup	Number of studies	Heterogeneity		Pooled results
			(%)	OR	95% CI	for OR
R versus Q
Overall	4	0.38	3.0	1.51	(1.10–2.07)	0.01
CP	3	0.22	33.2	1.42	(0.89–2.27)	0.15
AgP	1	NA	NA	1.62	(0.95–2.78)	0.08
Smokers	3	0.28	20.6	1.59	(1.14–2.22)	<0.05
Nonsmokers	1	NA	NA	1.14	(0.51–2.54)	0.75
RR versus QQ
Overall	4	0.44	0.0	1.46	(0.64–3.35)	0.37
CP	3	0.38	0.0	1.13	(0.41–3.11)	0.81
AgP	1	NA	NA	2.46	(0.59–10.32)	0.22
Smokers	3	0.32	11.6	1.14	(0.51–2.54)	0.27
Nonsmokers	1	NA	NA	0.83	(0.12–5.61)	0.85
QR versus QQ
Overall	4	0.67	0.0	1.79	(1.21–2.65)	<0.05
CP	3	0.52	0.0	1.92	(1.19–3.11)	<0.05
AgP	1	NA	NA	1.57	(0.80–3.05)	0.19
Smokers	3	0.49	0	1.84	(1.21–2.80)	<0.05
Nonsmokers	1	NA	NA	1.50	(0.52–4.36)	0.46
( RR + QR) versus QQ
Overall	4	0.53	0.0	1.75	(1.21–2.54)	<0.05
CP	3	0.34	7.4	1.79	(1.13–2.83)	0.01
AgP	1	NA	NA	1.67	(0.89–3.15)	0.11
Smokers	3	0.39	0	1.82	(1.22–2.72)	<0.05
Nonsmokers	1	NA	NA	1.34	(0.49–3.66)	0.56
RR versus (QQ + QR)
Overall	4	0.48	0.0	1.20	(0.55–2.64)	0.65
CP	3	0.47	0.0	0.90	(0.34–2.37)	0.83
AgP	1	NA	NA	2.15	(0.52–8.89)	0.29
Smokers	3	0.35	5.4	1.35	(0.56–3.25)	0.53
Nonsmokers	1	NA	NA	0.71	(0.11–4.60)	0.72