Research Article
Amniotic Fluid Infection in Preterm Pregnancies with Intact Membranes
Table 4
The accuracies of biomarkers based on ROC-curve and the odd ratios OR (95% CI) for MIAC.
| | | Cut-off value
ng/mL | AUC (95% CI) | Sensitivity | Specificity | OR (95% CI) |
| | Cascade 1 | | | | | | | MMP-8 | 48 | 0.985 (0.96–1.0) | 100 | 95.5 | 3.3 (1.3–8.6) | | MMP-9 | 57.5 | 0.991 (0.97–1.0) | 100 | 97 | 4.5 (1.3–15.3) | | MPO | 264 | 0.952 (0.88–1.0) | 100 | 74.2 | 1.4 (1.1–1.8) | | IL-6 | 5.1 | 0.974 (0.94–1.0) | 100 | 93.9 | 2.8 (1.3–6.0) | | Cascade 2 | | | | | | | HNE | 257 | 0.987 (0.97–1.0) | 100 | 97 | 4.5 (1.3–15.3) | | Elafin | 488.5 | 0.854 (0.68–1.0) | 85.7 | 86.4 | 38 (4.1–353.6) | | MMP-9 | 57.5 | 0.991 (0.97–1.0) | 100 | 97 | 4.5 (1.3–15.3) | | Cascade 3 | | | | | | | MMP-2 | 300.5 | 0.781 (0.65–0.91) | 85.7 | 71.2 | 14.8 (1.7–131.7) | | TIMP-1 | 1420.5 | 0.933 (0.87–1.0) | 100 | 80.3 | 1.5 (1.1–2.1) | | MMP-8 /TIMP-1 molar ratio | 0.01 | 0.985 (0.96–1.0) | 100 | 93.9 | 2.8 (1.3–6.0) | | CRP | 22 | 0.738 (0.56–0.91) | 100 | 40.9 | 1.2 (1.0–1.3) |
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MIAC, microbial invasion of the amniotic cavity.
MMP-8, matrix metalloproteinase-8; MMP-9, matrix metalloproteinase-9; MPO, myeloperoxidase; IL-6, interleukin-6; HNE, neutrophil elastase; MMP-2, matrix metalloproteinase-2; TIMP-1, tissue inhibitor of matrix metalloproteinase-1; CRP, C-reactive protein; LD, lactate dehydrogenase; Gluc, glucose.
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