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Disease Markers
Volume 2017, Article ID 8216723, 9 pages
Research Article

Relationship of the Content of Systemic and Endobronchial Soluble Molecules of CD25, CD38, CD8, and HLA-I-CD8 and Lung Function Parameters in COPD Patients

1Kazan Federal University, Kremlyovskaya St, 18, Kazan 420000, Russia
2Nizhny Novgorod State Medical Academy, Minin and Pozharsky Square 10/1, Nizhny Novgorod 603005, Russia
3Pulmonology Research Institute, 11-Parkovaya 32, Moscow 105077, Russia
4I.M. Sechenov First Moscow State Medical University, Trubetskaya, 8- 2, Moscow, Russia
5Lobachevsky State University of Nizhny Novgorod, Gagarina Avenue 23, Nizhny Novgorod 603950, Russia
6Centro de Investigación en Computación, Instituto Politécnico Nacional (CIC-IPN), Av. Juan de Dios Bátiz, Esq. Miguel Othón de Mendizábal S/N, Gustavo A. Madero, 07738 Mexico City, Mexico
7Central Clinical Hospital of RAS, Litovskiy Blvd. 1A, Moscow 117593, Russia

Correspondence should be addressed to Ildar Batyrshin; moc.liamg@1rytab

Received 15 April 2017; Revised 15 June 2017; Accepted 2 July 2017; Published 7 August 2017

Academic Editor: Giuseppe Murdaca

Copyright © 2017 Nailya Kubysheva et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The definition of new markers of local and systemic inflammation of chronic obstructive pulmonary disease (COPD) is one of the priority directions in the study of pathogenesis and diagnostic methods improvement for this disease. We investigated 91 patients with COPD and 21 healthy nonsmokers. The levels of soluble CD25, CD38, CD8, and HLA-I-CD8 molecules in the blood serum and exhaled breath condensate (EBC) in moderate-to-severe COPD patients during exacerbation and stable phase were studied. An unidirectional change in the content of sCD25, sCD38, and sCD8 molecules with increasing severity of COPD was detected. The correlations between the parameters of lung function and sCD8, sCD25, and sHLA-I-CD8 levels in the blood serum and EBC were discovered in patients with severe COPD. The findings suggest a pathogenetic role of the investigated soluble molecules of the COPD development and allow considering the content of sCD8, sCD25, and sHLA-I-CD8 molecules as additional novel systemic and endobronchial markers of the progression of chronic inflammation of this disease.