MicroRNAs Involvement in Radioresistance of Head and Neck Cancer

Figure 1

MiRNAs involved in radioresistance of head and neck cancer. This figure shows a regulation of key processes involved in head and neck cancers radioresistance through miRNAs and their targets. ANXA1: Annexin 1, BCL2: B-cell CLL/Lymphoma 2, ATM: Ataxia Telangiectasia Mutated, MCL1: Myeloid cell Leukemia 1, CD40LG: CD40 Ligand, MYB v-Myb: avian myeloblastosis viral oncogene homolog, SMC1A: Structural Maintenance of Chromosomal 1 A, CDH 1: Cadherin 1, PTEN: Phosphatase and Tensin homolog, XIAP: X-linked Inhibitor of Apoptosis E3 ubiquitin Protein, WNT2B: wingless-type MMTV integration site family member 2B, RAB14: member of RAS oncogene family, HIF-1α: hypoxia-inducible factor 1 alpha subunit, TGF-WNT: transforming growth factor-wingless-type MMTV integration site family, RECK: reversion-inducing cysteine rich protein with Kazal motifs, MDR1: Multi-Drug Resistance gene 1, IL8: Interleukin 8, HSP90AA1: Heat Shock protein 90 kDa Alpha (cytosolic) Class A Member 1, ICAM 1: Intercellular Adhesion Molecule 1, Myc v-Myc: Avian Myelocytomatosis viral oncogene homolog, ICAM 2: Intercellular Adhesion Molecule 2, CTNNB1: Catenin (Cadherin associated protein) Beta1, LEF1: Lymphoid Enhancer-Binding Factor 1, CDK1: Cyclin-Dependent Kinase 1, CXCR4: Chemokine (c-x-c motif) Receptor 4, WNT1: wingless-type MMTV integration site family member 1, TWIST1: Twist Basic Helix-Loop-Helix Transcription Factor 1.