Upregulation of FBXW7 Suppresses Renal Cancer Metastasis and Epithelial Mesenchymal Transition

<div>Overexpression of FBXW7 inhibited renal cancer cell migration and invasion. (a) The migration and invasion abilities were analyzed by Boyden chamber assay. (b) The migration was measured by wound healing assay. 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id="g113-49"></path></g><g transform="matrix(.013,0,0,-0.013,40.821,0)"><path d="M113 -12C146 -12 170 11 170 46C170 78 146 103 114 103S58 78 58 46C58 11 82 -12 113 -12Z" id="g113-47"></path></g><g transform="matrix(.013,0,0,-0.013,43.785,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z" id="g113-49"></path></g><g transform="matrix(.013,0,0,-0.013,50.025,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z" id="g113-50"></path></g></svg> based on the Student <i>t</i>-test. Data are represented as mean ± SD. (c) The expressions of MMP-2, MMP-9, and MMP-13 were measured by Western blotting. GAPDH was probed as the loading control. All results are from the three independent experiments.</div>

Disease Markers

fig2

Figure 2

Figure 2: Upregulation of FBXW7 Suppresses Renal Cancer Metastasis and Epithelial Mesenchymal Transition 