Peritumoral EpCAM Is an Independent Prognostic Marker after Curative Resection of HBV-Related Hepatocellular Carcinoma

Table 3

Cox proportional hazard regression analysis of patients’ overall survival.

Variables	Univariable			Multivariable
	Hazard ratio	95% CI	value	Hazard ratio	95% CI	value
Gender (female versus male)	0.785	0.493–1.332	0.407	—	—	—
Age (<50 versus ≥50)	0.551	0.316–0.830	0.004	0.608	0.331–1.111	0.106
AFP (≥400 ng/mL versus <400 ng/mL)	1.608	1.124–2.300	0.009	1.657	1.149–2.387	0.007
ALT (>80 IU/L versus ≤80 IU/L)	1.473	1.016–2.135	0.041	1.299	0.952–2.113	0.541
Albumin (>35 g/L versus ≤35 g/L)	0.327	0.540–1.228	0.327	—	—	—
Bilirubin (>20 μmol/L versus ≤20 μmol/L)	1.380	0.747–2.551	0.304	—	—	—
Number of tumor lesions (single versus multiple)	0.438	0.296–0.648	0.000	0.482	0.297–0.783	0.003*
Vascular invasion (absent versus present)	0.468	0.307–0.712	0.006	0.476	0.277–0.819	0.007*
Cirrhosis (absent versus present)	0.553	0.385–0.792	0.001	0.543	0.370–0.797	0.002*
Histological differentiation
Moderately versus well	1.146	0.674–1.948	0.614	—	—	—
Poorly versus well	1.593	0.840–3.020	0.153	—	—	—
Greatest tumor diameter
(≥5 cm versus <5 cm)	1.619	1.012–2.591	0.044	1.422	0.976–2.074	0.067
EpCAM (positive versus negative)	2.053	1.272–3.313	0.003	2.030	1.252–3.290	0.004
CD13 (positive versus negative)	1.625	1.022–2.502	0.040	1.469	0.908–2.378	0.117

CI: confidence interval; AFP: alpha-fetoprotein; ALT: alanine aminotransferase; indicates .