Peritumoral EpCAM Is an Independent Prognostic Marker after Curative Resection of HBV-Related Hepatocellular Carcinoma

Table 4

Cox proportional hazard regression analysis of recurrence-free survival.

Variables	Univariable			Multivariable
	Hazard ratio	95% CI	value	Hazard ratio	95% CI	value
Gender (female versus male)	0.695	0.417–1.156	0.161	—	—	—
Age (<50 versus ≥50)	0.762	0.521–1.235	0.167	—	—	—
AFP (≥400 ng/mL versus <400 ng/mL)	1.752	1.223–2.510	0.002	1.685	1.168–2.430	0.005
ALT (>80 IU/L versus ≤80 IU/L)	1.086	0.754–1.563	0.659	—	—	—
Albumin (>35 g/L versus ≤35 g/L)	0.767	0.528–1.114	0.164	—	—	—
Bilirubin (>20 μmol/L versus ≤20 μmol/L)	1.341	0.747–2.409	0.326	—	—	—
Number of tumor lesions (single versus multiple)	0.305	0.204–0.456	0.000	0.484	0.290–0.808	0.006
Macroscopic vascular invasion (absent versus present)	0.418	0.272–0.645	0.000	0.463	0.298–0.720	0.001
Cirrhosis (absent versus present)	0.681	0.476–0.972	0.034	0.604	0.419–0.872	0.007
Histological differentiation
Moderately versus well	1.060	0.624–1.800	0.830	—	—	—
Poorly versus well	1.374	0.720–2.623	0.336	—	—	—
Greatest tumor diameter
(≥5 cm versus < 5 cm)	1.204	0.854–1.697	0.290	—	—	—
EpCAM (positive versus negative)	1.767	1.078–2.895	0.024	1.622	0.986–2.669	0.057
CD13 (positive versus negative)	1.155	0.702–1.901	0.570	—	—	—

CI: confidence interval; AFP: alpha-fetoprotein; ALT: alanine aminotransferase; indicates .