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Disease Markers
Volume 2017 (2017), Article ID 8784971, 14 pages
Review Article

Crosstalk between Vitamins A, B12, D, K, C, and E Status and Arterial Stiffness

1Department of Functional Sciences, Discipline of Pathophysiology, “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania
22nd Department of Internal Medicine, “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania
3Department of Cardiology, “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania

Correspondence should be addressed to Dana Stoian; or.tfmu@anad.naiots

Received 8 October 2016; Accepted 14 December 2016; Published 12 January 2017

Academic Editor: Ying Huang

Copyright © 2017 Ioana Mozos et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Arterial stiffness is associated with cardiovascular risk, morbidity, and mortality. The present paper reviews the main vitamins related to arterial stiffness and enabling destiffening, their mechanisms of action, providing a brief description of the latest studies in the area, and their implications for primary cardiovascular prevention, clinical practice, and therapy. Despite inconsistent evidence for destiffening induced by vitamin supplementation in several randomized clinical trials, positive results were obtained in specific populations. The main mechanisms are related to antiatherogenic effects, improvement of endothelial function (vitamins A, C, D, and E) and metabolic profile (vitamins A, B12, C, D, and K), inhibition of the renin-angiotensin-aldosterone system (vitamin D), anti-inflammatory (vitamins A, D, E, and K) and antioxidant effects (vitamins A, C, and E), decrease of homocysteine level (vitamin B12), and reversing calcification of arteries (vitamin K). Vitamins A, B12, C, D, E, and K status is important in evaluating cardiovascular risk, and vitamin supplementation may be an effective, individualized, and inexpensive destiffening therapy.