Increased Levels of S100A8/A9 in Patients with Peritonsillar Abscess: A New Promising Diagnostic Marker to Differentiate between Peritonsillar Abscess and Peritonsillitis

<div>PTA score (<i>S</i><sub>PTA</sub>) was developed by the addition of one point each for symptoms like trismus, halitosis, uvula edema, unilateral swelling of the arched palate, S100A8/A9 &gt; 2550 ng/ml in the serum, and S100A8/A9 &gt; 8180 ng/ml in the saliva. Patients with acute tonsillitis, peritonsillitis, and peritonsillar abscess show significant higher <i>S</i><sub>PTA</sub> values in comparison with the controls. Furthermore, a significant difference of <i>S</i><sub>PTA</sub> values between the PTA and the PC cohort was detectable (a). ROC analysis of the PTA score revealed a cut-off value of <i>S</i><sub>PTA</sub> = 2.5 (sensitivity = 0.92, specificity = 0.93, <svg height="11.7782pt" id="M46" style="vertical-align:-3.42938pt" version="1.1" viewbox="-0.0498162 -8.34882 50.7895 11.7782" width="50.7895pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M570 304C570 398 525 448 414 448C385 448 343 445 312 434L329 511L321 518C297 504 262 482 244 460L233 411C195 397 159 381 128 358L135 332C160 347 189 360 224 373L111 -147C97 -210 84 -218 17 -231L13 -257L254 -247L259 -218L233 -216C183 -212 177 -202 189 -142L218 -1C238 -10 266 -12 283 -12C351 3 429 48 483 105C543 168 570 242 570 304ZM482 289C482 161 380 33 304 33C278 33 248 51 233 69L303 396C326 400 352 403 369 403C428 403 482 380 482 289Z" id="g113-113"></path></g><g transform="matrix(.013,0,0,-0.013,11.342,0)"><path d="M512 -3V55L134 254V256L512 456V514L75 281V230L512 -3Z" 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Disease Markers

fig6

Figure 6

Figure 6: Increased Levels of S100A8/A9 in Patients with Peritonsillar Abscess: A New Promising Diagnostic Marker to Differentiate between Peritonsillar Abscess and Peritonsillitis 

Figure 6 | Increased Levels of S100A8/A9 in Patients with Peritonsillar Abscess: A New Promising Diagnostic Marker to Differentiate between Peritonsillar Abscess and Peritonsillitis 