Plasma IL-37 Elevated in Patients with Chronic Heart Failure and Predicted Major Adverse Cardiac Events: A 1-Year Follow-Up Study

Table 2

Cox regression analysis for major adverse cardiac events.

Variables	Univariate analysis		Multivariable analysis
	Hazard ratio		Hazard ratio
	(95% CI)	value	(95% CI)	value
Age (years)	0.974 (0.944–1.005)	0.098
Male, n (%)	0.647 (0.342–1.225)	0.181
BMI (kg/m^2)	1.179 (1.010–1.376)	0.037	1.301 (1.042–1.623)	0.020
IHD, n (%)	1.489 (0.774–2.865)	0.233
Hypertension, n (%)	1.272 (0.679–2.384)	0.452
DM, n (%)	2.797 (1.435–5452)	0.003	3.077 (1.435–5.452)	0.027
LVEF (%)	0.800 (0.749–0.854)	<0.001	0.925 (0.848–1.009)	0.077
hs-TnT (pg/ml)	1.097 (1.060–1.136)	<0.001
hs-CRP (ng/ml)	1.982 (1.539–2.553)	<0.001
NT-proBNP (pg/ml)	1.001 (1.001–1.001)	<0.001	1.001 (1.000–1.001)	<0.001
IL-37 (pg/ml)	1.053 (1.043–1.064)	<0.001	1.038 (1.017–1.059)	<0.001