Circulating miR-132-3p as a Candidate Diagnostic Biomarker for Malignant Mesothelioma

Table 5

Sensitivity and specificity of the sequential algorithm for miR-132-3p/miR-126 and number of true positive, true negative, false positive, and false negative tests, calculated for maximum Youden’s Index (YI) and fixed false positive rates (FPRs) of 0%, 5%, and 11%.

FPR (%)	Cut-off		Sensitivity (%)	Specificity (%)	True positive ()	True negative ()	False positive ()	False negative ()
	Maximum YI	0.080							3.51	95	68	21	30	14	1
0	0.020	0.10	18	100	4	44	0	18
5	0.050	0.10	32	95	7	42	2	15
11	0.060	0.62	50	89	11	39	5	11