Table of Contents Author Guidelines Submit a Manuscript
Disease Markers
Volume 2017, Article ID 9306409, 9 pages
https://doi.org/10.1155/2017/9306409
Clinical Study

High Sensitivity Troponins Discriminate Different Morphologies of Coronary Artery Plaques Being Assessed by Coronary Computed Tomography Angiography

1First Department of Medicine, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany
2DZHK (German Center for Cardiovascular Research) Partner Site, Mannheim, Germany
3Institute of Clinical Radiology and Nuclear Medicine, Faculty of Medicine Mannheim, University Medical Center Mannheim (UMM) and Heidelberg University, Mannheim, Germany
4Institute of Clinical Chemistry, Laboratory Medicine and Transfusion Medicine, General Hospital Nuremberg and Paracelsus Medical University, Nuremberg, Germany

Correspondence should be addressed to Jonas Rusnak; ed.mmu@kansur.sanoj

Received 27 February 2017; Accepted 31 May 2017; Published 18 July 2017

Academic Editor: Serge Masson

Copyright © 2017 Jonas Rusnak et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. This study evaluates the association between high sensitivity troponin I (hsTnI) and T (hsTnT) and the morphology of coronary artery plaques detected by coronary computed tomography angiography (CCTA) in patients with suspected coronary artery disease (CAD). Methods. Patients undergoing CCTA were prospectively enrolled. CCTA was indicated by a low to intermediate pretest probability for CAD during routine clinical care. Within 24 hours of CCTA examination, peripheral blood samples were taken to measure hsTnI, hsTnT, and N-terminal probrain natriuretic peptide (NT-proBNP). Results. A total of 99 patients were enrolled with 43% without CAD, 9% with noncalcified plaques, 28% with calcified plaques, and 19% with mixed type plaque lesions. Both hsTnI and hsTnT levels were able to discriminate significantly between the groups, especially in the presence of mixed coronary plaques (AUC range: 0.741–0.752; ). In multivariate logistic regression models, hsTnT, but not hsTnI, was still significantly associated with mixed coronary plaque morphology (odds ratio = 8.968; 95% CI 1.999–40.241; ). Conclusions. Both hsTnI and hsTnT are able to discriminate between different coronary artery plaques morphologies, whereas hsTnT was significantly associated with mixed coronary plaques in patients with suspected CAD. This trial is registered with NCT03074253.