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Disease Markers
Volume 2017 (2017), Article ID 9389432, 5 pages
Research Article

New Markers of Inflammation and Tubular Damage in Children with Chronic Kidney Disease

1Department of Pediatric Nephrology, Wrocław Medical University, Wrocław, Poland
2Department of Pediatric Nephrology, Jagiellonian University, Kraków, Poland

Correspondence should be addressed to Kinga MusiaƂ

Received 30 May 2017; Revised 6 June 2017; Accepted 15 June 2017; Published 20 July 2017

Academic Editor: Natacha Turck

Copyright © 2017 Kinga Musiał et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Introduction and Aims. Monocyte chemoattractant protein- (MCP-) 1, macrophage colony-stimulating factor (MCSF), and neopterin are connected with monocyte migration and transition into macrophages, leading to fibrosis and tubular damage in the course of CKD. The aim of the study was to analyze the applicability of urinary fractional excretion (FE) of MCP1, MCSF, and neopterin, as markers of inflammation and tubular damage, in children with CKD. Methods. The study group consisted of 61 children with CKD stages 1–5 and 23 age-matched controls. The serum and urine concentrations of MCP1, MCSF, and neopterin were assessed by ELISA and then the fractional excretion (FE) was calculated. Results. FE MCSF and neopterin values exceeded 1% already in controls. FE MCSF rose significantly since CKD stages 1-2, FE neopterin since CKD stages 3–5. FE MCP1 was below 1% in healthy controls and in CKD stages 1-2, then increased significantly in CKD stages 3–5. Conclusions. The FE MCP-1 values show that inflammation precedes the tubular dysfunction. FE MCSF and FE neopterin may be considered new markers of the renal parenchyma progressive damage. Fractional excretion may become a useful tool in the assessment of inflammation and tubular damage in children with CKD.