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Disease Markers
Volume 2017, Article ID 9463272, 7 pages
https://doi.org/10.1155/2017/9463272
Research Article

The Impact of tagSNPs in CXCL16 Gene on the Risk of Myocardial Infarction in a Chinese Han Population

1Institute of Aging Research, Guangdong Medical University, Dongguan, China
2Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University, Dongguan, China
3Institute of Biochemistry & Molecular Biology, Guangdong Medical University, Zhanjiang, China
4Department of Clinical Laboratory, The Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
5Department of Cardiovascular Disease, The First People’s Hospital of Foshan, Foshan, China
6Department of Cardiovascular Disease, The Affiliated Hospital of Guangdong Medical University, Zhanjiang, China

Correspondence should be addressed to Xinguang Liu; moc.621@46uilgx and Xing-dong Xiong; moc.621@gnodgnixgnoix

Received 13 September 2016; Revised 25 December 2016; Accepted 22 January 2017; Published 14 February 2017

Academic Editor: Michele Malaguarnera

Copyright © 2017 Shun Xu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

CXCL16 has been demonstrated to be involved in the development of atherosclerosis and myocardial infarction (MI). Nonetheless, the role of the CXCL16 polymorphisms on MI pathogenesis is far to be elucidated. We herein genotyped four tagSNPs in CXCL16 gene (rs2304973, rs1050998, rs3744700, and rs8123) in 275 MI patients and 670 control subjects, aimed at probing into the impact of CXCL16 polymorphisms on individual susceptibility to MI. Multivariate logistic regression analysis showed that C allele (OR = 1.31, 95% CI = 1.03–1.66, and ) and CC genotype (OR = 1.84, 95% CI = 1.11–3.06, and ) of rs1050998 were associated with increased MI risk; and C allele (OR = 0.77, 95% CI = 0.60–0.98, and ) of rs8123 exhibited decreased MI risk, while the other two tagSNPs had no significant effect. Consistently, the haplotype rs2304973T-rs1050998C-rs3744700G-rs8123A containing the C allele of rs1050998 and A allele of rs8123 exhibited elevated MI risk (OR = 1.41, 95% CI = 1.02–1.96, and ). Further stratified analysis unveiled a more apparent association with MI risk among younger subjects (≤60 years old). Taken together, our results provided the first evidence that CXCL16 polymorphisms significantly impacted MI risk in Chinese subjects.