Research Article
The Impact of tagSNPs in CXCL16 Gene on the Risk of Myocardial Infarction in a Chinese Han Population
Table 3
Multivariate associations of the four tagSNPs in CXCL16 gene with the risk of MI.
| | Type | Controls () | Cases () | OR (95% CI) | value | | Number (%) | Number (%) |
| | rs2304973 | | | | | | C | 1221 (91.1) | 485 (88.2) | 1.00 | — | | T | 119 (8.9) | 65 (11.8) | 1.46 (1.00–2.12) | 0.050 | | CC | 555 (82.8) | 216 (78.5) | 1.00 | — | | CT | 111 (16.6) | 53 (19.3) | 1.31 (0.85–2.00) | 0.220 | | TT | 4 (0.6) | 6 (2.2) | 4.16 (0.96–18.03) | 0.057 | | CC | 555 (82.8) | 216 (78.5) | 1.00 | — | | CT + TT | 115 (17.2) | 59 (21.5) | 1.44 (0.96–2.17) | 0.080 | | rs1050998 | | | | | | T | 586 (43.7) | 215 (39.1) | 1.00 | — | | C | 754 (56.3) | 335 (60.9) | 1.31 (1.03–1.66) | 0.029 | | TT | 135 (20.1) | 38 (13.8) | 1.00 | — | | CT | 316 (47.2) | 139 (50.5) | 1.67 (1.03–2.70) | 0.037 | | CC | 219 (32.7) | 98 (35.6) | 1.84 (1.11–3.06) | 0.018 | | TT | 135 (20.1) | 38 (13.8) | 1.00 | — | | CT + CC | 535 (79.9) | 237 (86.2) | 1.74 (1.10–2.75) | 0.018 | | rs3744700 | | | | | | G | 1193 (89.0) | 487 (88.5) | 1.0 | — | | T | 147 (11.0) | 63 (11.5) | 1.05 (0.72–1.51) | 0.811 | | GG | 533 (79.6) | 216 (78.5) | 1.0 | — | | GT | 127 (19.0) | 55 (19.3) | 1.02 (0.68–1.56) | 0.905 | | TT | 10 (1.5) | 4 (1.5) | 0.80 (0.19–3.46) | 0.767 | | GG | 533 (79.6) | 216 (78.5) | 1.0 | — | | GT + TT | 137 (20.4) | 59 (21.5) | 1.04 (0.69–1.56) | 0.857 | | rs8123 | | | | | | A | 845 (63.1) | 377 (68.5) | 1.00 | — | | C | 495 (36.9) | 173 (31.5) | 0.77 (0.60–0.98) | 0.036 | | AA | 269 (40.1) | 130 (47.3) | 1.00 | — | | AC | 307 (45.8) | 117 (42.5) | 0.78 (0.55–1.11) | 0.163 | | CC | 94 (14.0) | 28 (10.2) | 0.58 (0.34–1.01) | 0.054 | | AA | 269 (40.1) | 130 (47.3) | 1.00 | — | | AC + CC | 401 (59.9) | 145 (52.7) | 0.73 (0.52–1.02) | 0.065 |
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Adjusted for age, sex, smoking, drinking, hypertension, diabetes, and hyperlipidemia.
P values under 0.05 were indicated in bold font.
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