Table of Contents Author Guidelines Submit a Manuscript
Disease Markers
Volume 2017, Article ID 9474532, 6 pages
https://doi.org/10.1155/2017/9474532
Research Article

Associations between the Epithelial-Mesenchymal Transition Phenotypes of Circulating Tumor Cells and the Clinicopathological Features of Patients with Colorectal Cancer

1Department of General Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266011, China
2Department of Gastrointestinal Surgery, The Affiliated Hospital of Binzhou Medical University, Binzhou, Shandong 256603, China
3Department of Ultrasound, The 3rd Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China
4Centers for Disease Control and Prevention of Binzhou City, Binzhou, Shandong 256603, China
5Center of Colon and Rectum, Qingdao Municipal Hospital, Qingdao, Shandong 266011, China

Correspondence should be addressed to Baoguang Hu; moc.361@nmlgbh and Dianliang Zhang; moc.621@ldzdhp

Received 16 May 2017; Accepted 2 November 2017; Published 21 December 2017

Academic Editor: Andreas Hillenbrand

Copyright © 2017 Fengjie Wu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. N. Normanno, A. De Luca, M. Gallo, N. Chicchinelli, and A. Rossi, “The prognostic role of circulating tumor cells in lung cancer,” Expert Review of Anticancer Therapy, pp. 1–9, 2016. View at Publisher · View at Google Scholar · View at Scopus
  2. S. Nagrath, R. M. Jack, V. Sahai, and D. M. Simeone, “Opportunities and challenges for pancreatic circulating tumor cells,” Gastroenterology, vol. 151, no. 3, pp. 412–426, 2016. View at Publisher · View at Google Scholar · View at Scopus
  3. J. E. Hardingham, P. Grover, M. Winter, P. J. Hewett, T. J. Price, and B. Thierry, “Detection and clinical significance of circulating tumor cells in colorectal cancer—20 years of progress,” Molecular Medicine, vol. 21, Supplement 1, pp. S25–S31, 2015. View at Publisher · View at Google Scholar · View at Scopus
  4. R. E. Payne, F. Wang, N. Su et al., “Viable circulating tumour cell detection using multiplex RNA in situ hybridisation predicts progression-free survival in metastatic breast cancer patients,” British Journal of Cancer, vol. 106, no. 11, pp. 1790–1797, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. W. S. Tsai, J. S. Chen, H. J. Shao et al., “Circulating tumor cell count correlates with colorectal neoplasm progression and is a prognostic marker for distant metastasis in non-metastatic patients,” Scientific Reports, vol. 6, no. 1, article 24517, 2016. View at Publisher · View at Google Scholar · View at Scopus
  6. E. A. Abdallah, M. F. Fanelli, V. Souza e Silva et al., “MRP1 expression in CTCs confers resistance to irinotecan-based chemotherapy in metastatic colorectal cancer,” International Journal of Cancer, vol. 139, no. 4, pp. 890–898, 2016. View at Publisher · View at Google Scholar · View at Scopus
  7. M. Pesta, V. Kulda, A. Narsanska, J. Fichtl, and O. Topolcan, “May CTC technologies promote better cancer management?” The EPMA Journal, vol. 6, no. 1, p. 1, 2015. View at Publisher · View at Google Scholar · View at Scopus
  8. C. D. Hart, F. Galardi, M. Pestrin, F. de Luca, E. Risi, and A. di Leo, “Using CTCs for pharmacogenomic analysis,” Pharmacological Research, vol. 106, pp. 92–100, 2016. View at Publisher · View at Google Scholar · View at Scopus
  9. M. M. Ferreira, V. C. Ramani, and S. S. Jeffrey, “Circulating tumor cell technologies,” Molecular Oncology, vol. 10, no. 3, pp. 374–394, 2016. View at Publisher · View at Google Scholar · View at Scopus
  10. A. Satelli, A. Mitra, Z. Brownlee et al., “Epithelial-mesenchymal transitioned circulating tumor cells capture for detecting tumor progression,” Clinical Cancer Research, vol. 21, no. 4, pp. 899–906, 2015. View at Publisher · View at Google Scholar · View at Scopus
  11. M. Mego, Z. Cierna, P. Janega et al., “Relationship between circulating tumor cells and epithelial to mesenchymal transition in early breast cancer,” BMC Cancer, vol. 15, no. 1, p. 533, 2015. View at Publisher · View at Google Scholar · View at Scopus
  12. H. Liu, X. Zhang, J. Li, B. Sun, H. Qian, and Z. Yin, “The biological and clinical importance of epithelial-mesenchymal transition in circulating tumor cells,” Journal of Cancer Research and Clinical Oncology, vol. 141, no. 2, pp. 189–201, 2015. View at Publisher · View at Google Scholar · View at Scopus
  13. T. T. Li, H. Liu, F. P. Li et al., “Evaluation of epithelial-mesenchymal transitioned circulating tumor cells in patients with resectable gastric cancer: relevance to therapy response,” World Journal of Gastroenterology, vol. 21, no. 47, pp. 13259–13267, 2015. View at Publisher · View at Google Scholar · View at Scopus
  14. S. Wu, S. Liu, Z. Liu et al., “Classification of circulating tumor cells by epithelial-mesenchymal transition markers,” PLoS One, vol. 10, no. 4, article e0123976, 2015. View at Publisher · View at Google Scholar · View at Scopus
  15. S. Wu, Z. Liu, S. Liu, L. Lin, W. Yang, and J. Xu, “Enrichment and enumeration of circulating tumor cells by efficient depletion of leukocyte fractions,” Clinical Chemistry and Laboratory Medicine, vol. 53, p. 337, 2015. View at Publisher · View at Google Scholar · View at Scopus
  16. S. K. Pal, M. He, T. Wilson et al., “Detection and phenotyping of circulating tumor cells in high-risk localized prostate cancer,” Clinical Genitourinary Cancer, vol. 13, no. 2, pp. 130–136, 2015. View at Publisher · View at Google Scholar · View at Scopus
  17. T. M. Gorges, I. Tinhofer, M. Drosch et al., “Circulating tumour cells escape from EpCAM-based detection due to epithelial-to-mesenchymal transition,” BMC Cancer, vol. 12, no. 1, p. 178, 2012. View at Publisher · View at Google Scholar · View at Scopus
  18. R. Harouaka, Z. Kang, S. Y. Zheng, and L. Cao, “Circulating tumor cells: advances in isolation and analysis, and challenges for clinical applications,” Pharmacology & Therapeutics, vol. 141, no. 2, pp. 209–221, 2014. View at Publisher · View at Google Scholar · View at Scopus
  19. Y. M. Li, S. C. Xu, J. Li et al., “Epithelial–mesenchymal transition markers expressed in circulating tumor cells in hepatocellular carcinoma patients with different stages of disease,” Cell Death & Disease, vol. 4, no. 10, article e831, 2013. View at Publisher · View at Google Scholar · View at Scopus
  20. L. Wan, K. Pantel, and Y. Kang, “Tumor metastasis: moving new biological insights into the clinic,” Nature Medicine, vol. 19, no. 11, pp. 1450–1464, 2013. View at Publisher · View at Google Scholar · View at Scopus
  21. F. Chen, S. Wang, Y. Fang et al., “Feasibility of a novel one-stop ISET device to capture CTCs and its clinical application,” Oncotarget, vol. 8, no. 2, pp. 3029–3041, 2017. View at Publisher · View at Google Scholar
  22. M. Mohme, S. Riethdorf, and K. Pantel, “Circulating and disseminated tumour cells - mechanisms of immune surveillance and escape,” Nature Reviews. Clinical Oncology, vol. 14, no. 3, pp. 155–167, 2017. View at Publisher · View at Google Scholar · View at Scopus