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Research Article

Risk Factors for the Development of Refeeding Syndrome-Like Hypophosphatemia in Very Low Birth Weight Infants

Table 3

Prevalence of postnatal complications and electrolyte disturbance during the first week of life in very low birth weight infants stratified according to serum phosphate levels.

ComplicationAll ()Hypophosphatemia ()Normophosphatemia () value

CLD at day 28, %68.8 (33/48)64.3 (9/14)70.6 (24/34)0.738
CLD at week 36, %52.1 (25/48)50.0 (7/14)52.9 (18/34)1.000
Home oxygen therapy, %14.9 (7/47)7.1 (1/14)18.2 (6/33)0.657
PDA, medically treated, %26.5 (13/49)20.0 (3/15)29.4 (10/34)0.727
PDA, surgically treated, %4.1 (2/49)6.7 (1/15)2.9 (1/34)0.523
IVH grades 3-4, %2.0 (1/49)6.7 (1/15)0 (0/34)0.306
Periventricular leukomalacia, %2.0 (1/49)6.7 (1/15)0 (0/34)0.306
Necrotizing enterocolitis, %6.1 (3/49)13.3 (2/15)2.9 (1/34)0.218
Hypoglycemia, %59.2 (29/49)73.3 (11/15)52.9 (18/34)0.221
Hypokalemia, %38.8 (19/49)73.3 (11/15)23.5 (8/34)0.002
Hypercalcemia, %34.7 (17/49)66.7 (10/15)20.8 (7/34)0.003
Urinary P/Cr, mg/mg0.18 (0–0.77)0 (0–0.07)0.50 (0.07–0.90)<0.001
Urinary K/Cr, mg/mg0.75 (0.46–1.52)0.45 (0.32–0.86)0.83 (0.59–1.90)0.010

Values are expressed as median (interquartile range) or frequency (n/N). Significant differences between the groups () are indicated in bold font. Ca: calcium; CLD: chronic lung disease; Cr: creatinine; IVH: intraventricular hemorrhage; P: phosphorus; PDA: patent ductus arteriosus.

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