PROM and Labour Effects on Urinary Metabolome: A Pilot Study

Table 1

Statistically significant (FDR < 0.05) metabolites from univariate analysis (ANOVA with Tukey’s HSD post hoc test) of the three classes Ph1, Ph2, and Ph3.

Metabolite	Chemical class	value	FDR	Tukey’s HSD
cis-Aconitic acid	Misc		0.00015894	2-1, 3-1, 3-2
2,3,4,5-Tetrahydroxypentanoic acid 1,4-lactone	Ox		0.00026357	2-1, 3-1, 3-2
Erythronic acid	Ox		0.00026357	2-1, 3-1, 3-2
3-Hydroxybutyric acid	Misc		0.00026357	3-1, 3-2
3,4-Dihydroxybutyric acid	Misc		0.00026357	2-1, 3-2
Glucaric acid	Ox		0.00026357	2-1, 3-2
Unknown C	Misc		0.00029809	3-1, 3-2
Pseudouridine	Misc		0.00029809	3-1, 3-2
Erythritol	SR		0.00030706	3-1, 3-2
Gulonic acid	Ox		0.00030706	3-1, 3-2
Monosaccharide 1886	SR		0.00030706	3-1, 3-2
Pyroglutamic acid	Misc		0.00033075	2-1, 3-2
Arabitol	SR		0.00033075	3-1, 3-2
Fucose	Carb		0.00033536	3-1, 3-2
Ribitol	SR		0.00034397	2-1, 3-2
Tyrosine	AA	0.00011408	0.00056327	2-1, 3-2
Xylobiose	Carb	0.00016349	0.00075975	3-2
3,4,5-Trihydroxypentanoic acid	Misc	0.00023492	0.0010311	2-1, 3-2
Histidine	AA	0.00027084	0.0011261	2-1, 3-2
Gluconic acid	Ox	0.00040226	0.0015889	3-2
Serine	AA	0.00050574	0.0019025	2-1, 3-2
Lysine	AA	0.0005569	0.0019615	2-1, 3-2
Monosaccharide E	SR	0.00058834	0.0019615	3-2
Xylitol	SR	0.00059589	0.0019615	3-1, 3-2
Phenylalanine	AA	0.00089953	0.0028425	2-1, 3-2
Threonine	AA	0.00098451	0.0029914	2-1, 3-2
Quinolinic acid	Misc	0.0012588	0.003683	2-1, 3-2
4-Deoxythreonic acid	SR	0.0014511	0.0040942	3-2
Cystine	AA	0.0015954	0.004346	3-2
Succinic acid	Misc	0.0024091	0.0063441	3-2
Alanine	AA	0.0027785	0.0070807	2-1, 3-2
N-Acetylglucosamine	SR	0.0035822	0.0088435	3-2
Phosphate	Misc	0.0037469	0.0089697	3-2
Ribonic acid	Ox	0.0042205	0.0098065	3-2
2-Amino-6-hydroxy-7-methyl-7H-purine	Misc	0.0043539	0.0098274	3-1, 3-2
Hydroxyproline dipeptide	AA	0.0048016	0.010537	2-1, 3-2
Maltose	Carb	0.0050599	0.010804	2-1, 3-1
Glutamine	AA	0.0055744	0.011425	2-1, 3-2
Glycine, N-4-hydroxybenzoyl	Misc	0.0057479	0.011425	2-1, 3-2
Threonic acid	Ox	0.005785	0.011425	2-1, 3-2
2-O-Glycerol-galactopyranoside	SR	0.006708	0.012925	2-1, 3-2
Lactose	Carb	0.0077141	0.01451	2-1, 3-2
Ribose	Carb	0.0088787	0.016312	3-2
Citric acid	Misc	0.0092274	0.016567	3-2
Galactose	Carb	0.010113	0.017412	3-1
4-Hydroxyphenylacetic acid	Misc	0.010139	0.017412	2-1, 3-2
Glucose	Carb	0.012002	0.020173	2-1
Glycine, N-4-hydroxybenzoyl derivative	Misc	0.018028	0.029671	3-2
Uric acid	Misc	0.0197	0.031761	3-2
Threitol	SR	0.020579	0.032514	3-2
Galactitol	SR	0.021507	0.033314	2-1
Hippuric acid	Misc	0.023726	0.035603	3-2
Creatinine	Misc	0.023885	0.035603	2-1, 3-2
2,4-Dihydroxybutyric acid	Misc	0.026377	0.038588	3-2
2-Ketogluconic acid	Ox	0.027386	0.039336	3-2
Arabinose	Carb	0.028179	0.039753	3-1
Sedoheptulose	Carb	0.028971	0.040153	3-2
4-Deoxyerythronic acid	Ox	0.034187	0.046565	3-2