Research Article
Association of Maternal and Fetal Single-Nucleotide Polymorphisms in Metalloproteinase (MMP1, MMP2, MMP3, and MMP9) Genes with Preeclampsia
Table 3
Comparison of maternal genotypes between the preeclamptic and study groups.
| | Maternal genotypes and alleles | PE group
N (%) | Control group
N (%) | | pHWE |
| | −1607 1G/2G MMP1 (rs1799750) | | | | | | 1G/1G | 30 (35%) | 14 (16%) | <0.01 | 0.712 | | 1G/2G | 22 (25%) | 43 (51%) | <0.01 | | 2G/2G | 34 (40%) | 28 (33%) | 0.369 | | 1G | 82 (48%) | 71 (42%) | 0.272 | | | 2G | 90 (52%) | 99 (58%) | |
| | −1171 5A/6A MMP3 (rs35068180) | | | | | | 5A/5A | 32 (37%) | 12 (14%) | <0.01 | 0.585 | | 5A/6A | 31 (36%) | 43 (51%) | 0.055 | | 6A/6A | 23 (27%) | 30 (35%) | 0.226 | | 5A | 95 (55%) | 67 (39%) | <0.01 | | | 6A | 77 (45%) | 103 (61%) | |
| | −1562C/T MMP9 (rs3918242) | | | | | | CC | 61 (71%) | 57 (67%) | 0.584 | 0.629 | | CT | 25 (29%) | 26 (31%) | 0.828 | | TT | 0 (0%) | 2 (2%) | 0.472 | | C | 147 (85%) | 140 (82%) | 0.433 | | | T | 25 (15%) | 30 (18%) | |
| | −735 C/T MMP2 (rs2285053) | | | | | | CC | 67 (78%) | 66 (78%) | 0.967 | 0.481 | | CT | 19 (22%) | 17 (20%) | 0.737 | | TT | 0 (0%) | 2 (2%) | 0.472 | | C | 153 (89%) | 149 (88%) | 0.707 | | | T | 19 (11%) | 21 (12%) | |
| | −1306 C/T MMP2 (rs243865) | | | | | | CC | 52 (60%) | 49 (58%) | 0.708 | 0.636 | | CT | 30 (35%) | 30 (35%) | 0.955 | | TT | 4 (5%) | 6 (7%) | 0.730 | | C | 134 (78%) | 128 (75%) | 0.568 | | | T | 38 (22%) | 42 (25%) | |
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For value analysis, the chi 2 or Yates’ corrected chi 2 tests were used; HWE: Hardy–Weinberg equilibrium. |
