Research Article
Association of Maternal and Fetal Single-Nucleotide Polymorphisms in Metalloproteinase (MMP1, MMP2, MMP3, and MMP9) Genes with Preeclampsia
Table 7
Haplotype association with the predisposition to preeclampsia.
| | Haplotype association with preeclampsia occurrence | MMP1 rs1799750 | MMP3 rs35068180 | MMP9 rs3918242 | MMP2 rs2285053 | MMP2 rs243865 | OR (95% Cl) | value |
| Maternal haplotype set | (1) | 2G | 6A | C | C | C | 1 | — | (2) | 1G | 5A | C | C | C | 0.78 (0.29–2.12) | 0.63 | (3) | 2G | 5A | C | C | C | 2.90 (0.92–9.17) | 0.072 | (4) | 1G | 6A | C | C | C | 2.64 (0.77–9.02) | 0.12 | (5) | 2G | 6A | C | C | T | 0.63 (0.18–2.21) | 0.47 | (6) | 2G | 6A | C | C | C | 1.66 (0.47–5.83) | 0.43 |
| Fetal haplotype set | (1) | 2G | 6A | C | C | C | 1 | — | (2) | 1G | 5A | C | C | C | 0.88 (0.28–2.75) | 0.82 | (3) | 2G | 5A | C | C | C | 0.36 (0.09–1.48) | 0.16 | (4) | 1G | 6A | C | C | C | 0.99 (0.28–3.44) | 0.98 | (5) | 2G | 6A | C | C | T | 0.37 (0.08–1.77) | 0.21 | (6) | 1G | 6A | C | C | T | 2.59 (0.61–11.09) | 0.2 | (7) | 1G | 5A | C | T | C | 2.34 (0.59–9.29) | 0.23 | (8) | 1G | 5A | C | C | T | 5.93 (1.06–33.19) | <0.05 | (9) | 2G | 5A | T | C | C | 0.98 (0.16–5.93) | 0.98 |
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OR: odds ratio; CI: confidence interval; result is statistically significant for value < 0.05. |