Growth Differentiation Factor-15 as a Predictor of Idiopathic Membranous Nephropathy Progression: A Retrospective Study

Figure 1

ROC curve and performance in predicting renal progression. ROC curve showing the prognostic sensitivity and specificity of GDF-15, PLA₂R Ab, UPCR, and initial eGFR with regard to renal progression. GDF-15 > 2.15 ng/ml demonstrates 80.8% specificity and 75.0% sensitivity in predicting disease progression. ROC: receiver operating characteristic; GDF: growth differentiation factor (green line); PLA₂R Ab: phospholipase A₂ receptor antibody (blue line); UPCR: spot urine protein-to-creatinine ratio (yellow line); eGFR: estimated glomerular filtration rate (violet line); AUC: area under the receiver operating characteristic curve.