Disease Markers

Research Article

Positive Association between EDN1 rs5370 (Lys198Asn) Polymorphism and Large Artery Stroke in a Ukrainian Population

Table 4

Analysis of EDN1 rs5370 and EDNRA rs5335 genotypic association with LAS.


Gene	SNP	Model	P_c	OR_c (95% CI)	P_a	OR_a (95% CI)

EDN1	rs5370	Dominant	0.012	1.657 (1.115–2.462)	0.020	1.601 (1.066–2.403)
		Recessive	0.007	2.839 (1.331–6.057)	0.003	3.251 (1.492–7.084)
		Additive^a	0.096	1.426 (0.938–2.168)	0.198	1.328 (0.862–2.046)
		Additive^a	0.003	3.291 (1.512–7.165)	0.002	3.637 (1.639–8.073)

EDNRA	rs5335	Dominant	0.189	1.335 (0.867–2.056)	0.110	1.440 (0.921–2.251)
		Recessive	0.790	0.932 (0.553–1.570)	0.767	0.922 (0.539–1.578)
		Additive	0.146	1.398 (0.890–2.196)	0.078	1.522 (0.954–2.429)
		Additive	0.634	1.156 (0.636–2.103)	0.545	1.210 (0.652–2.245)

SNP: single nucleotide polymorphism; CI: confidence interval; P_c: crude P value; OR_c: crude odds ratio; P_a: P value adjusted for age, sex, body mass index, arterial hypertension, type 2 diabetes mellitus, and smoking; OR_a: adjusted odds ratio. ^aUpper row in the additive model of inheritance—comparison between Aa and AA genotypes; lower row—between aa and AA genotypes.