Positive Association between EDN1 rs5370 (Lys198Asn) Polymorphism and Large Artery Stroke in a Ukrainian Population
Table 7
Characteristics of the LAS subjects stratified by EDN1 rs5370 genotype.
Parameter
Genotype
P value
PFDR
GG ()
GT ()
TT ()
Body mass index, kg/m2
28.1 ± 3.6
27.6 ± 3.8
28.4 ± 3.9
0.448
0.647
Systolic BP, mmHg
165.1 ± 29.3
171.3 ± 28.8
167.5 ± 25.9
0.372
0.642
Diastolic BP, mmHg
94.4 ± 14.9
99.3 ± 16.2
91.7 ± 13.3
0.034a
0.429
Pulse BP, mmHg
70.7 ± 20.2
71.9 ± 24.8
75.8 ± 22.5
0.600
0.720
Mean BP, mmHg
117.9 ± 18.5
123.3 ± 17.8
116.9 ± 15.2
0.099
0.429
Total cholesterol, mmol/L
4.91 ± 1.4
5.15 ± 1.6
4.74 ± 1.3
0.374
0.641
HDL cholesterol, mmol/L
1.02 ± 0.31
1.01 ± 0.31
0.96 ± 0.25
0.610
0.720
LDL cholesterol, mmol/L
3.10 ± 1.3
3.33 ± 1.5
2.89 ± 1.3
0.347
0.642
Triglyceride, mmol/L
1.65 ± 0.8
1.71 ± 0.8
1.58 ± 0.7
0.750
0.812
Prothrombin time, s
9.47 ± 2.0
9.38 ± 2.0
9.29 ± 2.0
0.900
0.900
Thrombin time, s
16.71 ± 3.7
16.49 ± 3.5
17.60 ± 4.0
0.395
0.642
Fibrinogen, g/L
4.21 ± 1.3
3.93 ± 1.2
3.64 ± 1.3
0.089
0.429
Fasting glucose, mmol/L
6.17 ± 1.7
6.06 ± 1.4
5.59 ± 1.0
0.236
0.642
n: number of cases; BP: blood pressure; HDL: high-density lipoprotein; LDL: low-density lipoprotein; PFDR: P value after false discovery rate adjustment. aNonsignificant difference between GG and GT genotypes () and between TT and GT genotypes () by Bonferroni post hoc test.
