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Disease Markers
Volume 2018, Article ID 1926308, 8 pages
Research Article

Vitamin D and Incidence of Prediabetes or Type 2 Diabetes: A Four-Year Follow-Up Community-Based Study

1Department of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu 610041, China
2Department of Endocrinology and Metabolism, Affiliated Hospital of Guilin Medical University, Guangxi 541001, China
3Department of Endocrinology and Metabolism, First People’s Hospital of Long Quanyi District, Chengdu 610100, China
4Cardiovascular Medicine Department, Chengdu First People’s Hospital, Chengdu 610016, China

Correspondence should be addressed to Haoming Tian; moc.621@999naitmh

Received 9 September 2017; Revised 20 December 2017; Accepted 16 January 2018; Published 18 March 2018

Academic Editor: Hubertus Himmerich

Copyright © 2018 Yun Gao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aim. To examine whether the baseline 25-hydroxyvitamin D [25(OH)D] level was predictive of the onset of prediabetes or type 2 diabetes (T2DM) in the Chinese population. Methods. This was a 4-year follow-up study that was conducted in the Chengdu region of China as part of the China National Diabetes and Metabolic Disorders Study. The study included 490 participants that were free of prediabetes and type 2 diabetes mellitus (T2DM) at baseline and had complete data by follow-up examinations. Glucose, insulin, and 25(OH)D levels were measured at baseline and at 4 years later. Prediabetes and T2DM were defined by results obtained from an oral glucose tolerance test. Results. Over a 4-year follow-up, 95 (48.5‰) developed prediabetes and 31 (15.8‰) individuals developed diabetes. Low 25(OH)D status was significantly associated with the risk of developing prediabetes [OR 3.01 (95% CI: 1.50–6.06), ] and T2DM [OR 5.61 (95% CI: 1.73–18.27), ] after adjustment for multiple potential confounders. In a multiple linear regression analysis, low baseline levels of 25(OH)D were an independent predictor of increased insulin resistance over a 4-year period (). Conclusions. The current prospective study suggests that low 25(OH)D levels might have contributed to the incidence of prediabetes or T2DM in Chinese individuals. This trial is registered with TR-CCH-ChiCTR-OCS-09000361.