Elevated Serum Levels of Mixed Lineage Kinase Domain-Like Protein Predict Survival of Patients during Intensive Care Unit Treatment

Figure 3

MLKL serum concentrations after three days of ICU treatment predict survival in critically ill patients. (a) Serum MLKL concentrations were measured in critically ill patients after three days of intensive care unit (ICU) treatment and compared to those measured at admission to the ICU, . Asterisks and open circles indicate outlier values. (b) Serum MLKL concentrations in critically ill patients were measured after three days of ICU treatment and analyzed with respect to patients’ survival. Asterisks and open circles indicate outlier values. (c, d) Kaplan-Meier survival curves of ICU patients are displayed, showing that patients with high MLKL levels on day three (>229.4 pg/ml) had a significantly impaired survival at the ICU (c) or overall (d) as compared to patients with low MLKL serum concentrations (<229.4 pg/ml). The respective values are given in the figure.

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