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Disease Markers
Volume 2018, Article ID 1984718, 15 pages
Review Article

The Potential of Angiogenin as a Serum Biomarker for Diseases: Systematic Review and Meta-Analysis

1Institute of Environmental Health, School of Public Health, Zhejiang University, Hangzhou 310058, China
2Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou 310058, China
3Program in Molecular and Cellular Biology, Zhejiang University, Hangzhou 310058, China
4Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310058, China

Correspondence should be addressed to Jinghao Sheng; nc.ude.ujz@gnehshj and Zhengping Xu; nc.ude.ujz@uxpz

Received 15 October 2017; Revised 2 January 2018; Accepted 11 January 2018; Published 15 March 2018

Academic Editor: Benoit Dugue

Copyright © 2018 Dongdong Yu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Angiogenin (ANG) is a multifunctional angiogenic protein that participates in both normal development and diseases. Abnormal serum ANG levels are commonly reported in various diseases. However, whether ANG can serve as a diagnostic or prognostic marker for different diseases remains a matter of debate. Methods. Here, we performed a systematic review and meta-analysis of the literature utilizing PubMed, Web of Science, and Scopus search engines to identify all publications comparing plasma or serum ANG levels between patients with different diseases and healthy controls, as were studies evaluating circulating ANG levels in healthy populations, pregnant women, or other demographic populations. Results. This study demonstrated that the serum ANG concentration in healthy populations was 336.14 ± 142.83 ng/ml and remained relatively stable in different populations and regions. We noted no significant differences in serum ANG levels between patients and healthy controls, except in cases in which patients suffered from cancer or cardiovascular diseases. The serum ANG concentrations were significantly higher in patients who developed colorectal cancer, acute myeloid leukemia, multiple myeloma, myelodysplastic syndromes, and heart failure than those in healthy controls. Conclusion. ANG has the potential of being a serum biomarker for cancers and cardiovascular diseases.