Pretreatment Hepatitis C Virus NS5A/NS5B Resistance-Associated Substitutions in Genotype 1 Uruguayan Infected Patients

Table 2

Amino acids substitutions in HCV NS5B protein from DAA treatment-naïve patients.

Subtype	Isolate	RAS	RAP	Resistance to DAA	Reference
1a	003	C451R		DSV	Trial Coral I - cohort 2
1a	020	A421V		BCV	[29]
1a	022	C451R		DSV	Trial Coral I - cohort 2
1a	037	S556G		DSV	[54, 55]
	037		A553G	—	[8]
1b	026		A421V	—	[29]
	026	Q556R		DSV	[12]
1b	036		A421V	—	[29]

Beclabuvir (BCV), dasabuvir (DSV). Trial Coral I - cohort 2 http://www.hcv-trials.com/showStudy.asp?Study=86 (Mantry PS. AASLD, 2015, Abs. 1084).