Testing a Combination of Markers of Systemic Redox Status as a Possible Tool for the Diagnosis of Late Onset Alzheimer’s Disease

Figure 1

Receiver operating characteristic (ROC) curves for multimarker panel (including hydroperoxides, uric acid, residual antioxidant power, thiols, and arylesterase) for the diagnosis of late onset Alzheimer’s disease. (a) Multivariate logistic model: specificity/sensitivity = 64%/79%; (b) score model: specificity/sensitivity = 61%/83%; (c) number of risk factor model; specificity/sensitivity = 61%/83%. Chart C: value “1” means that the subject present only one risk factor (e.g., thiols lower than its cut-off); “2”, subjects with two risk factors (e.g., thiols and arylesterase lower than their respective cut-offs); “3”, three risk factors and so on. See Materials and Methods section or the description of the models used for ROC calculation.

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