Disease Markers

Research Article

Testing a Combination of Markers of Systemic Redox Status as a Possible Tool for the Diagnosis of Late Onset Alzheimer’s Disease

Table 2

Cut-off values, odds ratios, and AUCs for the diagnosis of LOAD calculated for each single serum parameter.


	Cut-off	OR ()	AUC

AOPP	70 μmol/L	1.66 ()	0.563
Hydroperoxides	330 CU	1.72 ()	0.566
RAP	190 FRAP units	3.18 ()	0.640
Thiols	190 μmol/L	3.16 ()	0.640
Uric acid	279 μmol/L	4.14 ()	0.653
Homocysteine	14 μmol/L	2.17 ()	0.595
Paraoxonase	90 U/L	1.22 ()	0.525
Arylesterase	94 kU/L	2.89 ()	0.629
Total FeOx	510 U/L	1.56 ()	0.554

Cut-off points corresponding to the best compromise between specificity and sensitivity. Abbreviations: OR, odds ratio; LOAD: late onset Alzheimer’s disease; CVD: cardiovascular disease; AOPP, advanced oxidation protein products; total FeOx, total ferroxidase; RAP, residual antioxidant power; CU, Carr units (1 CU = 0.023 mmol/L of H₂O₂); FRAP units, ferric reduction antioxidant power (1 FRAP unit = 100 μmol/L of Fe³⁺ reduced to Fe²⁺).