Disease Markers / 2018 / Article / Tab 1 / Review Article
Association between MnSOD Val16Ala Polymorphism and Cancer Risk: Evidence from 33,098 Cases and 37,831 Controls Table 1 Characteristics of studies included in the meta-analysis.
Surname (ref) Year Country Ethnicity Cancer type Control source Genotype method Case Control MAF HWE Score Val/Val Val/Ala Ala/Ala All Val/Val Val/Ala Ala/Ala All Ambrosone et al. [60 ] 1999 USA Caucasian Breast PB PCR-RFLP 16 53 45 114 25 62 23 110 0.49 0.181 12 Mitrunen et al. [10 ] 2001 Finland Caucasian Breast PB PCR-RFLP 124 255 100 479 153 231 98 482 0.44 0.526 13 Wang et al. [7 ] 2001 USA Caucasian Lung HB Pyrosequencing 305 551 245 1101 288 628 323 1239 0.49 0.609 9 Green et al. [61 ] 2002 UK Caucasian Breast HB PCR-RFLP 13 17 9 39 8 22 6 36 0.47 0.175 5 Hirvonen et al. [62 ] 2002 Finland Caucasian MPM PB PCR-RFLP 6 11 3 20 15 36 12 63 0.48 0.248 9 Levine et al. [63 ] 2002 USA Mixed CRC PB PCR-RFLP 139 209 108 456 140 234 121 495 0.48 0.237 12 Li et al. [64 ] 2002 USA Caucasian Pancreatic PB PCR-RFLP 10 11 3 24 8 10 5 23 0.43 0.580 6 Stoehlmacher et al. [13 ] 2002 USA Caucasian CRC PB TaqMan 25 65 35 125 21 64 37 122 0.43 0.456 5 Egan et al. [16 ] 2003 USA Caucasian Breast PB PCR-RFLP 102 250 118 470 130 240 127 497 0.50 0.446 10 Lin et al. [65 ]a 2003 China Asian Lung HB PCR-RFLP 139 59 (Val/Ala + Ala/Ala) 198 233 99 (Val/Ala + Ala/Ala) 332 NA NA 10 Woodson et al. [66 ] 2003 USA Caucasian Prostate PB MALDI-TOF MS 43 98 58 199 49 102 40 191 0.48 0.330 12 Cai et al. [11 ] 2004 China Asian Breast PB PCR-RFLP 831 266 28 1125 884 290 23 1197 0.14 0.890 15 Hung et al. [8 ] 2004 Italy Caucasian Bladder HB PCR-RFLP 68 89 44 201 45 115 54 214 0.48 0.262 9 Ichimura et al. [67 ] 2004 Japan Asian Bladder HB PCR-RFLP 169 41 3 213 157 48 4 209 0.13 0.882 11 Knight et al. [68 ] 2004 Canada Caucasian Breast PB PCR-SSCP 107 187 105 399 90 195 87 372 0.50 0.350 14 Lan et al. [17 ] 2004 China Asian Lung PB Real-time PCR 93 23 3 119 81 30 1 112 0.14 0.321 10 Millikan et al. [69 ] 2004 USA African Breast PB TaqMan 259 372 129 760 196 357 124 677 0.45 0.083 13 Millikan et al. [69 ] 2004 USA Caucasian Breast PB TaqMan 273 681 311 1265 266 586 283 1135 0.49 0.269 13 Olson et al. [70 ] 2004 USA Caucasian Ovarian HB MALDI-TOF MS 27 64 27 118 51 87 39 177 0.47 0.869 9 Tamimi et al. [71 ] 2004 USA Caucasian Breast PB Mixedd 255 468 245 968 297 612 296 1205 0.50 0.584 15 Bergman et al. [9 ] 2005 Sweden Caucasian Breast PB Sequencing 33 73 12 118 43 88 43 174 0.50 0.879 11 Cheng et al. [72 ] 2005 China Asian Breast HB MassARRAY 343 115 11 469 545 183 11 739 0.14 0.322 11 Gaudet et al. [38 ] 2005 USA Caucasian Breast PB MALDI-TOF MS 253 511 270 1034 264 539 281 1084 0.49 0.862 14 Landi et al. [73 ] 2005 Spain Caucasian CRC HB APEX 94 164 77 335 88 151 64 303 0.46 0.958 5 Li et al. [74 ] 2005 USA Caucasian Prostate PB PCR-RFLP 132 288 147 567 190 379 195 764 0.50 0.829 14 Terry et al. [75 ] 2005 USA Caucasian Bladder HB MALDI-TOF MS 54 122 59 235 57 103 54 214 0.49 0.586 8 Ho et al. [18 ]c 2006 China Asian Lung HB PCR-RFLP 176 58 0 234 180 52 7 239 0.14 0.184 7 Lightfoot et al. [76 ] 2006 USA and UK Caucasian NHL PB TaqMan 211 463 229 903 358 713 371 1442 0.50 0.676 13 Slanger et al. [77 ] 2006 Germany Caucasian Breast PB TaqMan 144 318 152 614 263 528 289 1080 0.49 0.477 14 Wang et al. [78 ] 2006 USA Mixed NHL PB TaqMan 285 545 290 1120 240 486 211 937 0.48 0.240 13 Cengiz et al. [15 ]b 2007 Turkey Caucasian Bladder HB PCR-RFLP 34 (Val/Val + Val/Ala) 17 51 34 (Val/Val + Val/Ala) 19 53 NA NA 7 Choi et al. [37 ] 2007 USA Caucasian Prostate PB MALDI-TOF MS 112 239 104 455 293 610 311 1214 0.49 0.857 13 Choi et al. [37 ] 2007 USA African Prostate PB MALDI-TOF MS 7 15 6 28 39 52 31 122 0.47 0.112 10 Ergen et al. [79 ]c 2007 Turkey Caucasian Prostate HB PCR-RFLP 19 25 6 50 32 18 0 50 0.18 0.121 7 Han et al. [80 ] 2007 USA Caucasian Skin PB TaqMan 184 402 187 773 196 425 212 833 0.49 0.549 15 Johnatty et al. [81 ] 2007 Australia Caucasian Ovarian PB Real-time PCR 123 273 147 543 276 546 308 1130 0.49 0.269 11 Kang et al. [82 ] 2007 USA Caucasian Prostate PB TaqMan 275 578 297 1150 376 686 320 1382 0.48 0.835 13 Kang et al. [82 ] 2007 USA African Prostate PB TaqMan 31 57 15 103 122 194 79 395 0.45 0.906 11 Landi et al. [83 ] 2007 Italy Caucasian MPM HB APEX 16 27 37 80 98 170 81 349 0.48 0.661 9 di Martino et al. [84 ] 2007 USA Caucasian Esophageal HB PCR-RFLP 32 73 35 140 20 39 34 93 0.42 0.171 8 Murphy et al. [12 ] 2007 Ireland Caucasian Esophageal PB SNaPshot 44 103 60 207 60 113 48 221 0.47 0.703 11 Arsova-Sarafinovska et al. [85 ] 2008 Turkey Caucasian Prostate HB Real-time PCR 19 46 20 85 41 73 37 151 0.49 0.690 9 Cooper et al. [86 ] 2008 USA Caucasian Prostate PB TaqMan 602 1352 680 2634 423 789 424 1636 0.50 0.152 15 Dalan et al. [87 ] 2008 Turkey Caucasian Ovarian PB PCR-RFLP 30 19 6 55 28 17 6 51 0.28 0.196 7 Justenhoven et al. [88 ] 2008 Germany Caucasian Breast PB MALDI-TOF MS 159 312 133 604 163 313 145 621 0.49 0.824 14 Mikhak et al. [89 ] 2008 USA Caucasian Prostate PB TaqMan 156 320 166 642 162 331 159 652 0.50 0.695 14 Rajaraman et al. [90 ] 2008 USA Caucasian Brain HB TaqMan 129 262 123 514 122 220 109 451 0.49 0.617 10 Wheatley-Price et al. [91 ] 2008 USA Caucasian Pancreatic HB TaqMan 33 58 31 122 61 165 105 331 0.43 0.786 11 Zienolddiny et al. [92 ] 2008 Norway Caucasian Lung PB APEX 74 175 70 319 119 178 78 375 0.45 0.448 12 Eras-Erdogan et al. [93 ] 2009 Turkey Caucasian Breast PB PCR-RFLP 107 113 30 250 150 141 39 330 0.33 0.508 8 Funke et al. [94 ] 2009 Germany Caucasian CRC PB Pyrosequencing 136 321 166 623 146 294 163 603 0.49 0.554 12 Iguchi et al. [95 ] 2009 USA Mixed Prostate HB PCR-RFLP 41 86 60 187 40 96 39 175 0.50 0.199 6 Kostrykina et al. [96 ] 2009 Russia Caucasian Breast PB TaqMan 123 233 119 475 103 183 90 376 0.48 0.622 12 Tong et al. [14 ]a 2009 Korea Asian Cervical HB SNaPshot 72 27 (Val/Ala + Ala/Ala) 99 194 69 (Val/Ala + Ala/Ala) 263 NA NA 7 Ermolenko et al. [97 ] 2010 Russia Caucasian Breast HB Real-time PCR 228 454 239 921 121 235 104 460 0.48 0.620 9 Ezzikouri et al. [98 ] 2010 Morocco Caucasian HCC PB PCR-RFLP 21 45 30 96 81 101 40 222 0.41 0.388 11 Ibrahim et al. [99 ] 2010 Egypt African HCC HB PCR-RFLP 16 32 27 75 19 28 11 58 0.43 0.904 8 Kim et al. [100 ] 2010 Korea Asian Breast HB TaqMan 234 66 4 304 279 90 7 376 0.14 0.934 11 Méplan et al. [101 ] 2010 Czech Caucasian CRC HB AS-PCR 172 358 189 719 165 318 174 657 0.49 0.415 9 Tang et al. [102 ] 2010 USA Mixed Pancreatic HB TaqMan 143 278 137 558 167 309 162 638 0.50 0.429 11 Wu et al. [103 ] 2010 China Asian Oral HB Real-time PCR 91 28 2 121 88 32 2 122 0.15 0.637 9 Yi et al. [104 ] 2010 China Asian Gastric HB SNaPshot 85 48 7 140 119 27 1 147 0.10 0.690 9 Cerne et al. [105 ] 2011 Slovenia Caucasian Breast HB TaqMan 118 269 143 530 65 134 71 270 0.51 0.910 8 Cheng et al. [106 ]b 2011 USA Mixed Prostate PB MALDI-TOF MS 152 (Val/Val + Val/Ala) 50 202 1054 (Val/Val + Val/Ala) 374 1428 NA NA 13 Mohelnikova-Duchonova et al. [107 ] 2011 Czech Caucasian Pancreatic PB Real-time PCR 66 121 48 235 73 134 58 265 0.47 0.812 10 Zhang et al. [108 ]b 2011 USA Mixed Pancreatic PB TaqMan 129 (Val/Val + Val/Ala) 60 189 365 (Val/Val + Val/Ala) 121 486 NA NA 13 Atoum et al. [109 ]c 2012 Jordan Caucasian Breast HB PCR-RFLP 22 43 0 65 11 6 0 17 0.18 0.377 6 Farawela et al. [110 ] 2012 Egypt African NHL PB PCR-RFLP 10 50 40 100 12 49 39 100 0.37 0.568 9 Hemelrijck et al. [111 ] 2012 Germany Caucasian Prostate PB MassARRAY 50 100 53 203 80 190 90 360 0.49 0.285 13 Kucukgergin et al. [112 ] 2012 Turkey Caucasian Bladder HB PCR-RFLP 52 68 37 157 89 99 36 224 0.38 0.341 8 Kucukgergin et al. [113 ] 2012 Turkey Caucasian Prostate HB PCR-RFLP 43 65 26 134 66 69 24 159 0.37 0.398 8 Tsai et al. [114 ]a 2012 China Asian Breast HB Real-time PCR 192 68 (Val/Ala + Ala/Ala) 260 138 86 (Val/Ala + Ala/Ala) 224 NA NA 8 Ye et al. [115 ] 2012 China Asian NPC HB PCR 88 15 2 105 110 23 3 136 0.11 0.191 8 Zhao et al. [116 ] 2012 China Asian Brain HB OpenArray 241 107 31 379 293 81 6 380 0.12 0.882 11 Amr et al. [117 ] 2013 Egypt African Bladder PB TaqMan 127 188 99 414 109 160 87 356 0.47 0.065 13 Ashour et al. [118 ] 2013 Egypt African Lung PB TaqMan 17 27 6 50 21 25 4 50 0.33 0.355 9 Attatippaholkun and Wikainapakul [119 ] 2013 Thailand Asian Cervical HB SNaPshot 64 39 4 107 84 48 3 135 0.20 0.184 7 Attatippaholkun et al. [119 ] 2013 Thailand Asian Breast HB SNaPshot 82 54 5 141 84 48 3 135 0.20 0.184 7 Eken et al. [120 ] 2013 Turkey Caucasian Prostate HB Real-time PCR 7 17 9 33 31 37 13 81 0.39 0.726 8 Han et al. [121 ] 2013 Korea Asian Pancreatic PB PCR-SSCP 190 85 19 294 236 59 5 300 0.12 0.558 12 Méplan et al. [122 ] 2013 Denmark Caucasian Breast PB TaqMan 228 485 226 939 237 494 227 958 0.49 0.331 14 Atilgan et al. [123 ] 2014 Turkey Caucasian RCC HB Probe 10 17 14 41 23 19 8 50 0.35 0.244 5 Liu et al [124 ] 2014 China Asian OSCC HB PCR-RFLP 272 83 7 362 296 61 1 358 0.09 0.243 10 Oskina et al. [125 ] 2014 Russia Caucasian Prostate PB TaqMan 92 194 94 380 86 152 99 337 0.48 0.076 12 Brown et al. [126 ] 2015 USA Mixed Medulloblastoma PB Illumina SNP chip 3 15 8 26 18 18 9 45 0.40 0.264 5 Jablonska et al. [127 ] 2015 Polish Caucasian Breast PB Real-time PCR 32 75 29 136 41 92 50 183 0.48 0.915 10 Parlaktas et al. [128 ] 2015 Turkey Caucasian Prostate HB Probe 23 23 3 49 24 20 5 49 0.31 0.784 7 Su et al. [129 ] 2015 China Asian HCC HB PCR-RFLP 334 78 10 422 359 107 13 479 0.14 0.150 7
MAF: minor allele frequency; HWE: Hardy-Weinberg equilibrium; HB: hospital-based; PB: population based; NA, not applicable; PCR-RFLP: polymorphism chain reaction-restriction fragment length polymorphism; MALDI-TOF MS: matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry; PCR-SSCP: polymorphism chain reaction-single strand conformation polymorphism; APEX: arrayed primer extension; AS-PCR: allele specific-polymorphism chain reaction; MPM: malignant pleural mesothelioma; CRC: colorectal cancer; NHL: non-Hodgkin’s lymphoma; HCC: hepatocellular carcinoma; RCC: renal cell carcinoma; OSCC: oral squamous cell carcinoma.
a Lin et al. [
65 ], Tong et al. [
14 ], and Tsai et al. [
114 ] were only calculated for the dominant model.
b Cengiz et al. [
15 ], Cheng et al. [
106 ], and Zhang et al. [
108 ] were only calculated for the recessive model.
c Ho et al. [
18 ], Ergen et al. [
79 ], and Atoum et al. [
109 ] were only calculated for the heterozygous model, dominant model, and allele comparison, and the number of Ala/Ala genotype was zero.
d Mixed: which included more than one genotyping methods.