The Circular RNA hsa_circ_0001445 Regulates the Proliferation and Migration of Hepatocellular Carcinoma and May Serve as a Diagnostic Biomarker

Figure 2

Overexpression of hsa_circ_0001445 promoted apoptosis and inhibited proliferation, migration, and invasion of HCC cells in vitro. (a) hsa_circ_0001445 expression levels were downregulated in the HCC-derived cell lines HepG2, Hep3B, HCCLM9, and MHCC97L. (b) The expression of hsa_circ_0001445 was significantly increased in HepG2 cells after transfection with pcDNA3.1(+)-circRNA-hsa_circ_0001445 for 24 h. (c) As indicated by the CCK8 assay, overexpression of hsa_circ_0001445 in HepG2 cells inhibited their proliferation. (d) Overexpression of hsa_circ_0001445 promoted apoptosis in HepG2 cells. (e) Overexpression of hsa_circ_0001445 decreased the migration capacity of HepG2 cells. (f) Overexpression of hsa_circ_0001445 impaired the invasion ability of HepG2 cells. , . Error bar indicates S.E.M. NC: negative control.

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