The Circular RNA hsa_circ_0001445 Regulates the Proliferation and Migration of Hepatocellular Carcinoma and May Serve as a Diagnostic Biomarker

Table 3

Diagnostic value of plasma hsa_circ_0001445 levels, serum AFP alone, and the combination of these two markers for the detection of HCC.

Biomarker	Subgroup	AUC	95% CI	Sen	Spe
hsa_circ_0001445	HCC versus control	0.862	0.796–0.927	0.942	0.712	<0.001
AFP	HCC versus control	0.767	0.694–0.840	0.644	1.000	<0.001
Combination	HCC versus control	0.970	0.949–0.991	0.875	0.942	<0.001
hsa_circ_0001445	HCC versus cirrhosis	0.672	0.586–0.758	0.740	0.544	<0.001
AFP	HCC versus cirrhosis	0.669	0.583–0.754	0.529	0.827	<0.001
Combination	HCC versus cirrhosis	0.743	0.664–0.821	0.625	0.788	<0.001
hsa_circ_0001445	HCC versus hepatitis B	0.764	0.686–0.842	0.692	0.727	<0.001
AFP	HCC versus hepatitis B	0.637	0.549–0.725	0.375	0.955	0.008
Combination	HCC versus hepatitis B	0.877	0.817–0.938	0.808	0.818	<0.001

Sen: sensitivity; Spe: specificity; HCC: hepatocellular carcinoma; AFP: alpha-fetoprotein.