Identification of Core Biomarkers Associated with Outcome in Glioma: Evidence from Bioinformatics Analysis

Table 3

KEGG pathway analysis of differentially expressed genes associated with glioma.

Expression	Term	Count	Ratio (%)	value	Genes	FDR
Upregulated	hsa04110: cell cycle	23	3.333333	3.25 − 11	CDK1, E2F5, TP53, TTK, CHEK1, CDC20, CDK6, MCM2, SFN, CDK4, TGFB1, WEE1, CDK2, MCM5, CCNB1, CCND1, MAD2L1, CCNB2, CDKN2C, BUB1, BUB1B, MYC, CCNA2	4.06 − 08
	hsa04512: ECM-receptorinteraction	19	2.753623	1.55 − 10	TNC, COL3A1, HSPG2, ITGA2, ITGA4, COL4A6, COL5A1, HMMR, LAMA2, LAMA1, LAMA4, LAMB2, CD36, CD44, COL6A3, COL1A2, COL6A2, COL6A1, COL1A1	1.94 − 07
	hsa04115: p53 signaling pathway	17	2.463768	1.72 − 10	STEAP3, CDK1, TP53, CHEK1, CDK6, SFN, PMAIP1, CDK4, CDK2, CCNB1, TP53I3, CCND1, CCNB2, RRM2, CASP8, SERPINE1, FAS	2.16 − 07
	hsa05200: pathways in cancer	32	4.637681	2.06 − 06	WNT5A, STK36, ERBB2, MMP9, LPAR4, CXCL8, GLI2, TGFB1, TCF7L1, LAMB2, CXCR4, CASP8, FAS, MYC, BMP2, TGFBR1, TP53, ITGA2, BIRC5, CDK6, FZD2, CDK4, MECOM, COL4A6, CDK2, FZD6, LAMA2, SMO, LAMA1, LAMA4, CCND1, F2R	2.58 − 03
	hsa05161: hepatitis B	18	2.608696	3.02 − 06	TGFBR1, MMP9, TP53, HSPG2, CXCL8, TLR3, BIRC5, CDK6, CDK4, CDK2, TGFB1, CCND1, CASP8, CREB3L4, FAS, MYC, CCNA2, NFATC1	3.78 − 03
Downregulated	hsa04723: retrograde endocannabinoid signaling	38	3.015873	1.92 − 20	ADCY1, GABRB3, GABRB2, GABRB1, ADCY5, RIMS1, KCNJ3, SLC32A1, PLCB4, CNR1, MGLL, GNG3, PLCB1, GNG7, GABRD, GABRG1, GABRG2, GABRA2, GABRA1, GABRA4, GABRA5, PRKCG, GRIA3, GRIA4, GRM1, ITPR1, PRKCB, SLC17A7, GRM5, SLC17A6, KCNJ6, KCNJ9, GRIA2, FAAH, GNB5, CACNA1D, CACNA1A, CACNA1B	2.45 − 17
	hsa04724: glutamatergic synapse	40	3.174603	2.94 − 20	ADCY1, GRIK2, ADCY5, PPP3R1, GRIN3A, KCNJ3, SLC1A2, PLCB4, GRIN2C, SLC1A6, PPP3CB, DLG4, GNG3, PPP3CA, PLCB1, SLC1A1, GNG7, DLGAP1, GRIN2A, PRKCG, GRIA3, GRIA4, HOMER1, GRM1, SHANK2, SHANK3, ITPR1, PRKCB, GRM5, SLC17A7, GRM3, GRM2, SLC17A6, GRIA2, GRM7, GNB5, PLA2G4C, CACNA1D, GRK3, CACNA1A	3.76 − 17
	hsa05032: morphine addiction	32	2.539683	2.87 − 16	ADCY1, GABRB3, GABRB2, ADCY5, GABRB1, GABBR1, GABBR2, ADORA1, KCNJ3, SLC32A1, PDE1C, PDE4A, PDE1A, GNG3, GNG7, GABRG1, GABRD, GABRG2, GABRA2, GABRA1, GABRA4, GABRA5, PRKCG, PDE10A, PRKCB, KCNJ6, PDE2A, KCNJ9, GNB5, GRK3, CACNA1A, CACNA1B	4.22 − 13
	hsa04727: GABAergic synapse	30	2.380952	2.91 − 15	ADCY1, SLC6A1, GABRB3, GABRB2, ADCY5, GABRB1, GABBR1, GABBR2, SLC32A1, PLCL1, GAD2, GNG3, GAD1, NSF, GNG7, GABRG1, GABRD, GABRG2, GABARAPL1, GABRA2, GABRA1, GABRA4, GABRA5, PRKCG, PRKCB, KCNJ6, GNB5, CACNA1D, CACNA1A, CACNA1B	3.69 − 12
	hsa04020: calcium signaling pathway	43	3.412698	5.62 − 15	SLC8A3, ADCY1, ERBB3, CAMK2G, PPP3R1, ITPKA, ATP2B2, ATP2B3, PLCB4, GRIN2C, PDE1C, PTK2B, PDE1A, PPP3CB, CAMK2B, PPP3CA, PLCB1, CAMK2A, NOS1, SLC8A2, CCKBR, CACNA1I, GRIN2A, PRKCG, GRM1, ITPR1, PRKCB, P2RX5, GRM5, GNAL, ADRB1, CAMK4, CHRM3, CHRM1, CACNA1G, RYR1, RYR2, CACNA1E, CACNA1D, HTR2C, CACNA1A, CACNA1B, HTR2A	7.24 − 12

KEGG: Kyoto Encyclopedia of Genes and Genomes; FDR: false discovery rate.