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Disease Markers
Volume 2018, Article ID 3452739, 7 pages
Research Article

Identification of Common Genes Refers to Colorectal Carcinogenesis with Paired Cancer and Noncancer Samples

1Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
2Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, China
3Haikou People’s Hospital and Affiliated Haikou Hospital of Xiangya Medical School, Central South University, Haikou, Hainan 570311, China
4State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, 54 South Xianlie Road, Guangzhou, Guangdong, China

Correspondence should be addressed to Hong-Hao Zhou; moc.361@3002uohzhh and Zhi-Rong Tan; moc.361@028008natrz

Received 21 June 2017; Accepted 16 October 2017; Published 30 January 2018

Academic Editor: Stamatios E. Theocharis

Copyright © 2018 Lihua Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Colorectal cancer is a malignant tumor which harmed human beings’ health. The aim of this study was to explore common biomarkers associated with colorectal carcinogenesis in paired cancer and noncancer samples. At first, fifty-nine pairs of colorectal cancer and noncancer samples from three gene expression datasets were collected and analyzed. Then, 181 upregulation and 282 downregulation common differential expression genes (DEGs) were found. Next, functional annotation was performed in the DAVID database with the DEGs. Finally, real-time polymerase chain reaction (PCR) assay was conducted to verify the analyses in sixteen colorectal cancer and individual-matched adjacent mucosa samples. Real-time PCR showed that MCM2, RNASEH2A, and TOP2A were upregulated in colorectal cancer compared with adjacent mucosa samples (MCM2, ; RNASEH2A, ; TOP2A, ). These suggested that 463 DEGs might contribute to colorectal carcinogenesis.