Haplotypes of TNFα/β Genes Associated with Sex-Specific Paranoid Schizophrenic Risk in Tunisian Population
Table 3
Distribution of genotype and allele frequencies of rs909253, rs1799724, and rs361525 in control subjects and patients with different subtypes of schizophrenia.
Genotype
n (%)
value
OR (95% CI)
Allele
n (%)
value
OR (95% CI)
rs909253
AA
AG
GG
A
G
Controls ()
111 (53.4)
79 (38)
18 (8.6)
301 (72.4)
115 (27.6)
Undifferentiated type ()
36 (41.9)
40 (46.5)
10 (11.6)
0.07
1.58 (0.95–2.65)
112 (65.1)
60 (34.9)
0.08
1.4 (0.95–2.04)
Disorganized type ()
15 (41.7)
16 (44.4)
5 (13.9)
0.2
1.59 (0.77–3.33)
46 (63.9)
26 (36.1)
0.1
1.47 (0.86–2.49)
Paranoid type ()
33 (38.4)
37 (43)
16 (18.6)
0.01
1.83 (1.1–3.08)
103 (59.9)
69 (40.1)
0.003
1.75 (1.20–2.54)
rs1799724
CC
CT
TT
C
T
Controls ()
170 (81.7)
35 (16.8)
3 (1.5)
375 (90.2)
41 (9.8)
Undifferentiated type ()
72 (83.7)
13 (15.1)
1 (1.2)
0.6
0.87 (0.4–1.68)
157 (91.3)
15 (8.7)
0.6
0.87 (0.45–1.60)
Disorganized type ()
28 (77.8)
6 (16.7)
2 (5.5)
0.5
1.27 (0.5–2.9)
62 (86.1)
10 (13.9)
0.3
1.47 (0.67–3.03)
Paranoid type ()
47 (54.7)
35 (40.7)
4 (4.6)
3.69 (2.12–6.44)
129 (75)
43 (25)
3.04 (1.89–4.89)
rs361525
GG
GA
AA
G
A
Controls ()
104 (50)
80 (38.5)
24 (11.5)
288 (69.2)
128 (30.8)
Undifferentiated type ()
31 (36.05)
43 (50)
12 (13.95)
0.02
1.77 (1.05–2.99)
105 (61.05)
67 (38.95)
0.05
1.43 (0.98–2.07)
Disorganized type ()
14 (38.9)
17 (47.2)
5 (13.9)
0.2
1.56 (0.76–3.30)
45 (62.5)
27 (37.5)
0.2
1.34 (0.79–2.26)
Paranoid type ()
17 (19.8)
50 (58.1)
19 (22.1)
4.04 (2.25–7.50)
84 (48.8)
88 (51.2)
2.35 (1.63–3.39)
This represented association was observed under the dominant model. . The chi-square test was used to evaluate the significant association between disease (schizophrenia against controls) and TNFA or LTA alleles or genotypes. The Fisher exact test was used to determine whether significant differences were observed when the patient group was compared with the control group and having total less than 5.
